{"id":"W3210048613","doi":"10.1016/j.semcdb.2021.10.004","title":"Bridging the gap between non-canonical and canonical Wnt signaling through Vangl2","year":2021,"lang":"en","type":"review","venue":"Seminars in Cell and Developmental Biology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Wnt signaling pathway; LRP5; LRP6; Beta-catenin; Frizzled; Non canonical; Cell biology; Biology; Cell polarity; Signal transduction; Computational biology; Genetics; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00057055,0.0005653201,0.001163482,0.00007134062,0.0002103227,0.00005618255,0.0003763608,0.0007806799,0.00004727717],"category_scores_gemma":[0.00005933888,0.0004132529,0.0001757533,0.0002188961,0.0004131744,0.000006331883,0.0008684416,0.0005334436,0.000009922347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001071653,"about_ca_system_score_gemma":0.001073499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004969692,"about_ca_topic_score_gemma":0.00003112549,"domain_scores_codex":[0.9972795,0.0002423733,0.0007573304,0.0009972692,0.0001290048,0.0005945367],"domain_scores_gemma":[0.9991831,0.0002311205,0.0002141229,0.0002204156,0.00003814299,0.0001130753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004540827,0.0001017806,0.008628469,0.00294463,0.0006338132,0.0001183965,0.0007232726,0.000001684376,0.00843107,0.00008239498,0.007565611,0.9707235],"study_design_scores_gemma":[0.000453501,0.0001158991,0.00005784123,0.002817987,0.0001717866,0.0001951374,0.0002264394,9.88974e-7,0.007105515,0.00005708071,0.9879847,0.0008131134],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01889875,0.9789029,0.0001052772,0.0000509882,0.0002708914,0.0003970194,0.00004043546,0.000009915747,0.001323784],"genre_scores_gemma":[0.009770066,0.9852473,0.002507079,0.0002247672,0.0003819814,0.0001227267,0.0008765116,0.00005340233,0.0008162006],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9804191,"threshold_uncertainty_score":0.9998319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03675818394772382,"score_gpt":0.3150337271071095,"score_spread":0.2782755431593856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}