{"id":"W3210068951","doi":"10.26434/chemrxiv.13728112.v1","title":"Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium Tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-Cholest-4,22- Dien-24-Oyl-CoA","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brookhaven National Laboratory; Office of Science; National Institutes of Health; National Institute of Advanced Industrial Science and Technology; University of British Columbia; McGill University; U.S. Department of Energy","keywords":"Chemistry; Biochemistry; Enzyme; NAD+ kinase; Cofactor; Stereochemistry; Isomerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009407366,0.0002286706,0.0001587733,0.000124288,0.0001327985,0.0002578867,0.0001696379,0.0002359648,0.0003922526],"category_scores_gemma":[0.0001412521,0.0001402331,0.0002225837,0.000214239,0.0001794893,0.0001348644,0.0001842975,0.0002968892,0.0002767705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003805776,"about_ca_system_score_gemma":0.0002511264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001923477,"about_ca_topic_score_gemma":0.001778176,"domain_scores_codex":[0.9999398,0.0000081763,0.000005095056,0.00001441652,0.00001979281,0.00001268031],"domain_scores_gemma":[0.9999447,0.000006314548,0.00002241934,0.000007204525,0.000007152652,0.00001221025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001230299,0.00003998754,0.00572593,0.00006329744,0.000009744829,0.0002515097,0.00008461309,0.000213991,0.9905095,0.0001746706,0.00005530972,0.002748313],"study_design_scores_gemma":[0.00004475765,0.0002872435,0.05831943,0.00001823822,0.00002527221,0.001502943,0.0002805842,0.002739597,0.9318286,0.0003039245,0.004636145,0.00001324441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987882,0.0004051404,0.0003853884,0.00005482205,0.000006675801,0.000004261611,0.00008619818,0.00001642575,0.0002529334],"genre_scores_gemma":[0.9973363,0.0003558247,0.001135257,0.00002530398,0.000004039412,0.000005748996,0.0004116759,0.000005505311,0.0007203338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001923477,"threshold_uncertainty_score":0.003824592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101071085056996,"score_gpt":0.2240288501445435,"score_spread":0.2130181392939735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}