{"id":"W3210068951","doi":"10.26434/chemrxiv.13728112.v1","title":"Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium Tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-Cholest-4,22- Dien-24-Oyl-CoA","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brookhaven National Laboratory; Office of Science; National Institutes of Health; National Institute of Advanced Industrial Science and Technology; University of British Columbia; McGill University; U.S. Department of Energy","keywords":"Chemistry; Biochemistry; Enzyme; NAD+ kinase; Cofactor; Stereochemistry; Isomerase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002971851,0.0004900225,0.0005906179,0.00005371375,0.00005474242,0.00005120595,0.0007028301,0.0008755088,0.00005634229],"category_scores_gemma":[0.0002605659,0.0004330451,0.0003952215,0.0002059242,0.0002226036,0.00001004157,0.001238038,0.0004338088,0.000002328467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001082176,"about_ca_system_score_gemma":0.0001634735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002447253,"about_ca_topic_score_gemma":0.00005050266,"domain_scores_codex":[0.9972979,0.0001174353,0.001004157,0.0008815909,0.0003647973,0.0003340663],"domain_scores_gemma":[0.9973128,0.00003932315,0.0008037333,0.001492728,0.0002598989,0.00009148619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000944308,0.0002369462,0.01246379,0.001442164,0.000116205,0.000002116044,0.0002170735,0.0001146085,0.9849729,0.000001384649,0.0001566593,0.0001817393],"study_design_scores_gemma":[0.0006154582,0.00004143845,0.02657765,0.0006746359,0.00008184924,0.00001390233,0.0001760079,0.00005555214,0.9711955,0.00002751426,0.000159596,0.0003809166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974565,0.0007997452,0.00006138965,0.0002628369,0.0003392731,0.0003981385,0.00003953121,0.00001294805,0.0006296215],"genre_scores_gemma":[0.9970583,0.0004103415,0.0001669217,0.00009637543,0.0002659449,0.00009436793,0.001212008,0.0000477687,0.0006479422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01411387,"threshold_uncertainty_score":0.9998121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101071085056996,"score_gpt":0.2240288501445435,"score_spread":0.2130181392939735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}