{"id":"W3210161753","doi":"10.1038/s41467-021-26526-y","title":"The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto; Hospital for Sick Children; Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; Japan Society for the Promotion of Science; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Mutation; KRAS; Upstream (networking); Cancer; Genetics; Cancer research; Biology; Computational biology; Computer science; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285145,0.000292323,0.0002624912,0.0001682698,0.0001745303,0.0003059868,0.0001556966,0.0002799541,0.001308164],"category_scores_gemma":[0.0001279347,0.0001989905,0.0002299715,0.0001357256,0.0003337264,0.0001721072,0.0002245009,0.0004918597,0.0004479429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002182889,"about_ca_system_score_gemma":0.000205037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006754668,"about_ca_topic_score_gemma":0.0008981746,"domain_scores_codex":[0.9998481,0.00002373987,0.00002223329,0.00002456438,0.00005148572,0.00002971218],"domain_scores_gemma":[0.9998649,0.00003171682,0.00003765809,0.00002452878,0.000007836985,0.00003324738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006258759,0.00002838883,0.0002562332,0.00001187472,0.000004398561,0.0001045665,0.000009779867,0.0001243658,0.998207,0.0002296816,0.0000372715,0.0009238443],"study_design_scores_gemma":[0.00003391656,0.0003839798,0.004183963,0.00000343352,0.000008632445,0.000844433,0.00002671817,0.001693998,0.9907769,0.0001191789,0.001919221,0.00000558999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957967,0.000254419,0.002158198,0.0001175233,0.00003035838,0.00003479454,0.0002516919,0.00006699221,0.001289278],"genre_scores_gemma":[0.9968592,0.0002615134,0.001087324,0.0000476994,0.000006802349,0.00002661617,0.0003002515,0.00002363475,0.001386897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001308164,"threshold_uncertainty_score":0.004376292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009755964029651709,"score_gpt":0.2833247719830886,"score_spread":0.2735688079534369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}