{"id":"W3210173014","doi":"10.1093/cvr/cvab334","title":"The molecular makeup of peripheral and central baroreceptors: stretching a role for Transient Receptor Potential (TRP), Epithelial Sodium Channel (ENaC), Acid Sensing Ion Channel (ASIC), and Piezo channels","year":2021,"lang":"en","type":"review","venue":"Cardiovascular Research","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; SIDS Calgary Society","keywords":"Mechanotransduction; Baroreflex; Epithelial sodium channel; Transient receptor potential channel; Baroreceptor; Ion channel; Neuroscience; Acid-sensing ion channel; Medicine; Mechanosensitive channels; Cell biology; Internal medicine; Receptor; Endocrinology; Biology; Chemistry; Blood pressure; Heart rate; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.003704116,0.0009738825,0.002832291,0.0004971587,0.001592414,0.000648201,0.0007914145,0.0007874577,0.00001365161],"category_scores_gemma":[0.0009249467,0.000721702,0.003218853,0.0009638104,0.001121325,0.0002190466,0.0006892266,0.001612402,0.000005094042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002567086,"about_ca_system_score_gemma":0.000550391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009128,"about_ca_topic_score_gemma":0.000004368459,"domain_scores_codex":[0.9892429,0.003198939,0.001089835,0.002084292,0.002234548,0.002149549],"domain_scores_gemma":[0.9970227,0.0005494251,0.0002901973,0.0009741848,0.0005600544,0.0006034331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001449913,0.0001055665,3.927415e-8,0.007159102,0.001497435,0.0001490135,0.003059716,0.0005003833,0.01308141,0.0001777869,0.0003570162,0.9737675],"study_design_scores_gemma":[0.00200994,0.0005344243,3.662028e-7,0.007655169,0.001151129,0.0006480296,0.003116621,0.004682885,0.07352187,0.000211857,0.9050108,0.00145695],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004552175,0.9831271,0.004139269,0.0001968316,0.003669604,0.003780724,0.0004344635,0.00006354035,0.00003628476],"genre_scores_gemma":[0.02025092,0.9760827,0.0001510989,0.00002011467,0.002648453,0.0002754221,0.0001316907,0.0002660021,0.0001735781],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9723106,"threshold_uncertainty_score":0.9997074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06113232551602854,"score_gpt":0.3260711174860298,"score_spread":0.2649387919700013,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}