{"id":"W3210269937","doi":"10.14309/01.ajg.0000776956.67877.43","title":"S856 Efficacy of Upadacitinib Induction Therapy in Patients With Moderately to Severely Active Ulcerative Colitis by Biologic Inadequate Responder Status: Results From Two Randomized Phase 3 Studies","year":2021,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Internal medicine; Ulcerative colitis; Clinical endpoint; Placebo; Gastroenterology; Randomization; Clinical trial; Randomized controlled trial; Phases of clinical research; Surgery; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004370987,0.0009310162,0.003197838,0.0003553817,0.0004278453,0.0009593643,0.0006664654,0.00137223,0.00297237],"category_scores_gemma":[0.002523272,0.0004687702,0.002519554,0.0005437984,0.0008394179,0.0007900526,0.0003939859,0.002117718,0.000408502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006588378,"about_ca_system_score_gemma":0.0009468347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004367618,"about_ca_topic_score_gemma":0.001518038,"domain_scores_codex":[0.9984824,0.0009512281,0.0001825548,0.0001421606,0.0001174067,0.0001242524],"domain_scores_gemma":[0.9978362,0.0008199565,0.0006858736,0.000169171,0.000134991,0.0003538483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9103588,0.007443753,0.002800986,0.002160118,0.003474698,0.00007402152,0.0001154895,0.0004692719,0.007785032,0.0001015485,0.000841379,0.06437494],"study_design_scores_gemma":[0.8359469,0.1490641,0.01041128,0.0001230063,0.001978959,0.0001098387,0.00002760645,0.0003153732,0.0009612576,0.00009705996,0.0009394769,0.00002517341],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789147,0.01501717,0.0006972491,0.0006402093,0.0001686823,0.002174978,0.0006373288,0.00009131581,0.00165843],"genre_scores_gemma":[0.9926438,0.003293834,0.0008944321,0.0006231091,0.0002002695,0.001180648,0.0006272318,0.0000107591,0.0005259349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004370987,"threshold_uncertainty_score":0.02311629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01494763496713507,"score_gpt":0.2930711175654535,"score_spread":0.2781234825983184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}