{"id":"W3210275542","doi":"10.1186/s12916-021-02131-0","title":"Placenta mediates the effect of maternal hypertension polygenic score on offspring birth weight: a study of birth cohort with fetal growth velocity data","year":2021,"lang":"en","type":"article","venue":"BMC Medicine","topic":"Pregnancy and preeclampsia studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Research Foundation","funders":"Japan Society for the Promotion of Science; Tokyo Medical and Dental University","keywords":"Medicine; Birth weight; Mendelian randomization; Offspring; Intrauterine growth restriction; Blood pressure; Population; Single-nucleotide polymorphism; Obstetrics; Pregnancy; Fetus; Cohort; Low birth weight; Gestational age; Internal medicine; Physiology; Endocrinology; Genetics; Biology; Genotype; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002218022,0.0005595032,0.0003817645,0.0006279178,0.0005728495,0.0005723864,0.0005041495,0.0003875786,0.001291748],"category_scores_gemma":[0.003393323,0.0003281632,0.0012936,0.0008615017,0.0003471215,0.0002444024,0.0005247121,0.0006757321,0.0001077966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002717268,"about_ca_system_score_gemma":0.0006405636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01714269,"about_ca_topic_score_gemma":0.01139608,"domain_scores_codex":[0.9988727,0.0004078858,0.00006988633,0.000377479,0.0001329685,0.000139004],"domain_scores_gemma":[0.9978241,0.0006492115,0.0004944382,0.0005580839,0.0001491832,0.0003250125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005010696,0.00003489588,0.9952269,0.000008931944,0.0006456746,0.0001861908,0.0001445075,0.0001113664,0.001366022,0.00009158626,0.00008054281,0.001602349],"study_design_scores_gemma":[0.00001381295,0.00009138239,0.9981585,0.000003015292,0.0004020029,0.0001217479,0.00005115071,0.000805254,0.0001679062,0.0000577579,0.0001232837,0.000004066142],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986781,0.0001685781,0.0006942298,0.00004379149,0.000008994927,0.000006518355,0.0002460054,0.000008877594,0.0001448095],"genre_scores_gemma":[0.9992163,0.00005623706,0.0003282374,0.00001241661,0.000004549212,0.000007342516,0.0002021232,0.000005599108,0.0001672284],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01714269,"threshold_uncertainty_score":0.03408581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03612985107337298,"score_gpt":0.267865743912521,"score_spread":0.231735892839148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}