{"id":"W3210301436","doi":"10.1016/j.hfc.2021.07.008","title":"New Frontiers in the Treatment of Homozygous Familial Hypercholesterolemia","year":2021,"lang":"en","type":"review","venue":"Heart Failure Clinics","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Sanofi Genzyme; Swedish Orphan Biovitrum; Shire; Sanofi; Pfizer; Amgen","keywords":"Medicine; Familial hypercholesterolemia; Intensive care medicine; Genetic disorder; Disease; Bioinformatics; Therapeutic approach; Atherosclerotic cardiovascular disease; Genetic enhancement; Internal medicine; Cholesterol; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001155082,0.001007063,0.003052227,0.002127684,0.0002523228,0.001407342,0.00111413,0.001615026,0.003881815],"category_scores_gemma":[0.001513211,0.0003261707,0.001128047,0.001683007,0.0005726131,0.001475361,0.000816801,0.003813317,0.001222787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005734357,"about_ca_system_score_gemma":0.0009019347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001331972,"about_ca_topic_score_gemma":0.003406829,"domain_scores_codex":[0.9996922,0.00007965118,0.00005600282,0.00004349201,0.00009812551,0.00003059021],"domain_scores_gemma":[0.9992716,0.0004614879,0.00009076379,0.00001304797,0.0001102465,0.00005296987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002781354,0.0001455291,0.0001787866,0.02471839,0.000330157,0.000229579,0.00004528298,0.0003145163,0.0009358235,0.00283201,0.02691767,0.943074],"study_design_scores_gemma":[0.000442579,0.0005340788,0.002221672,0.01951662,0.001385211,0.00155586,0.000108213,0.0003753888,0.0003397845,0.004602388,0.9688556,0.00006264319],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00003363828,0.9994363,0.00004829686,0.0001992609,0.0001275404,0.000001667058,0.000005254114,0.0000033281,0.0001447092],"genre_scores_gemma":[0.0003336442,0.9988141,0.0001163884,0.0003224786,0.0002717176,0.000003454652,0.00001352517,8.873388e-7,0.0001238217],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003881815,"threshold_uncertainty_score":0.01298594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04920559397896947,"score_gpt":0.3591121878491755,"score_spread":0.309906593870206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}