{"id":"W3210306469","doi":"10.15252/emmm.202115098","title":"P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"H2020 European Research Council; Olav Thon Stiftelsen; Demensfonden; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; National Institutes of Health; Orionin Tutkimussäätiö; UK Dementia Research Institute; Vetenskapsrådet; Academy of Finland; Fondation Vaincre Alzheimer; Ministerio de Ciencia, Innovación y Universidades; EU Joint Programme – Neurodegenerative Disease Research; Gun och Bertil Stohnes Stiftelse; European Commission; Instituto de Salud Carlos III; Familjen Erling-Perssons Stiftelse; Alzheimer's Drug Discovery Foundation; National Institute on Aging; Alzheimer's Association","keywords":"Biomarker; Disease; Medicine; Computational biology; Oncology; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003620156,0.0003096986,0.0005882547,0.0001459007,0.0001231874,0.00002021796,0.0001262469,0.00009562603,0.0006099251],"category_scores_gemma":[0.00104059,0.0002440814,0.0003298376,0.0003772997,0.0002598994,0.00006866712,0.0001062286,0.0002075826,0.00005441179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006205902,"about_ca_system_score_gemma":0.0008400649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002068574,"about_ca_topic_score_gemma":0.000001814003,"domain_scores_codex":[0.9972528,0.00008750886,0.000477514,0.0007169965,0.000828093,0.0006370618],"domain_scores_gemma":[0.9969607,0.000251286,0.00008965665,0.000777525,0.0004583144,0.001462518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.02674183,0.02553132,0.1515736,0.003384633,0.2380577,0.07740533,0.001317615,0.00004404499,0.2482037,0.01725473,0.08079797,0.1296875],"study_design_scores_gemma":[0.1270595,0.006218019,0.5663368,0.006627074,0.07792222,0.001049591,0.001378949,0.01466269,0.06639338,0.008621503,0.1204515,0.003278833],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4543645,0.366415,0.04648964,0.1067361,0.001565548,0.007642767,0.0006926199,0.0006853163,0.0154085],"genre_scores_gemma":[0.9898523,0.0002737439,0.00347461,0.00421956,0.0003769393,0.0002781543,0.001102173,0.00009487617,0.0003276162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5354878,"threshold_uncertainty_score":0.995335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09971361988776022,"score_gpt":0.410829516778453,"score_spread":0.3111158968906927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}