{"id":"W3210306469","doi":"10.15252/emmm.202115098","title":"P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease","year":2021,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University","funders":"H2020 European Research Council; Olav Thon Stiftelsen; Demensfonden; Reta Lila Weston Institute of Neurological Studies, UCL Queen Square Institute of Neurology,University College London; National Institutes of Health; Orionin Tutkimussäätiö; UK Dementia Research Institute; Vetenskapsrådet; Academy of Finland; Fondation Vaincre Alzheimer; Ministerio de Ciencia, Innovación y Universidades; EU Joint Programme – Neurodegenerative Disease Research; Gun och Bertil Stohnes Stiftelse; European Commission; Instituto de Salud Carlos III; Familjen Erling-Perssons Stiftelse; Alzheimer's Drug Discovery Foundation; National Institute on Aging; Alzheimer's Association","keywords":"Biomarker; Disease; Medicine; Computational biology; Oncology; Internal medicine; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001051919,0.001139798,0.0006390754,0.002146979,0.0003065168,0.001002192,0.0004895374,0.000767466,0.001064245],"category_scores_gemma":[0.0009016211,0.0002742501,0.0003753561,0.0006953076,0.0004651277,0.0006415836,0.000399646,0.0007351643,0.0006214065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003206389,"about_ca_system_score_gemma":0.0004990175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003762282,"about_ca_topic_score_gemma":0.0005261866,"domain_scores_codex":[0.9995963,0.0001072039,0.00003071364,0.0001019334,0.000117416,0.0000465113],"domain_scores_gemma":[0.999657,0.0000557319,0.0001137193,0.00001831436,0.00006964421,0.00008563583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003119002,0.0004326226,0.05288683,0.0007289808,0.0003257981,0.001110597,0.0002227357,0.000861669,0.8013939,0.0009817476,0.001626465,0.1363096],"study_design_scores_gemma":[0.0002366263,0.006924103,0.202168,0.0002489134,0.0009857611,0.01276742,0.0003330118,0.01336981,0.7344394,0.004004516,0.02432365,0.0001987473],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9195619,0.03909352,0.03350013,0.0006784732,0.0003719171,0.0002548377,0.001425856,0.0007973645,0.004315808],"genre_scores_gemma":[0.9619896,0.004816481,0.02965281,0.0001908006,0.0002000899,0.0001140697,0.0006741545,0.00003247527,0.002329488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002146979,"threshold_uncertainty_score":0.00556314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09971361988776022,"score_gpt":0.410829516778453,"score_spread":0.3111158968906927,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}