{"id":"W3210382301","doi":"10.1007/s12192-021-01242-0","title":"Caspase-mediated cleavage of miRNA processing proteins Drosha, DGCR8, Dicer, and TRBP2 in heat-shocked cells and its inhibition by HSP70 overexpression","year":2021,"lang":"en","type":"article","venue":"Cell Stress and Chaperones","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"","keywords":"Drosha; Dicer; Cell biology; Ribonuclease III; microRNA; Biology; Hsp70; Proteostasis; Cleavage (geology); Biogenesis; Caspase; Apoptosis; RNA interference; Heat shock protein; Programmed cell death; RNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000439121,0.0001420365,0.0001545324,0.00003010365,0.00006614064,0.0000294494,0.00002853649,0.000146871,0.00001007967],"category_scores_gemma":[0.00001362249,0.0001376663,0.00001850664,0.00005889467,0.00007040046,0.0000154109,0.00009313514,0.00005698103,2.471575e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000708332,"about_ca_system_score_gemma":0.00003255702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000371205,"about_ca_topic_score_gemma":0.00004274353,"domain_scores_codex":[0.9991816,0.00004672995,0.0001917385,0.0003383897,0.00009029901,0.0001512031],"domain_scores_gemma":[0.9996785,0.000009241099,0.00007701974,0.0001000157,0.00004992893,0.00008530647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006161485,0.0001257856,0.001088985,0.0005581255,0.000005278759,0.000005699996,0.0001532811,0.000004135063,0.9969801,0.000002622084,0.00009949171,0.0009149153],"study_design_scores_gemma":[0.0009641877,0.00007838711,0.004717724,0.0003291329,0.00001282429,0.000004519944,0.0002565942,0.0003994349,0.9928704,0.00001339926,0.0002013414,0.0001520766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798889,0.0195447,0.00003119022,0.0000438481,0.00001560031,0.0002155173,0.0001794647,0.000005581659,0.00007519411],"genre_scores_gemma":[0.9972174,0.002135673,0.00006127897,0.00002709381,0.00003368022,0.00001965499,0.0003977485,0.00001659002,0.00009084659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01740903,"threshold_uncertainty_score":0.5613869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005460804218391759,"score_gpt":0.2064866472620765,"score_spread":0.2010258430436848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}