{"id":"W3210425830","doi":"10.1039/d1fo02472h","title":"Naringenin prolongs lifespan and delays aging mediated by IIS and MAPK in <i>Caenorhabditis elegans</i>","year":2021,"lang":"en","type":"article","venue":"Food & Function","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"Tianjin Science and Technology Program; Natural Science Foundation of Tianjin City; National Natural Science Foundation of China","keywords":"Naringenin; Caenorhabditis elegans; Antioxidant; Oxidative stress; Chemistry; Downregulation and upregulation; Reactive oxygen species; MAPK/ERK pathway; Cell biology; CTL*; Biochemistry; Signal transduction; Biology; In vitro; Flavonoid; Gene; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001359489,0.0001560784,0.0001404192,0.00004123442,0.00008492079,0.00005111032,0.00005367029,0.0001689366,0.00001489656],"category_scores_gemma":[0.00005504267,0.000176865,0.00002718214,0.00009605188,0.00005128144,0.000008824202,0.0001025268,0.0001281147,0.000003270436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001196623,"about_ca_system_score_gemma":0.00004156957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000591213,"about_ca_topic_score_gemma":0.0006232299,"domain_scores_codex":[0.9989876,0.00005902456,0.0001768624,0.0004334918,0.0001046922,0.0002383541],"domain_scores_gemma":[0.9996005,0.00001094275,0.00005303935,0.0001846896,0.00006007823,0.00009075511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002295713,0.00006377405,0.04048096,0.00006008645,0.00008732997,0.00001038412,0.0005773325,0.00002597945,0.953555,0.00002230157,0.001353899,0.003533312],"study_design_scores_gemma":[0.003714512,0.00881655,0.06585924,0.0000752355,0.0001914934,0.000252146,0.000870772,0.0006808556,0.8061475,0.0004498153,0.1118436,0.001098277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990983,0.006197807,0.00192748,0.0003888894,0.0002002645,0.000122997,0.0000276087,0.00002017481,0.0001317836],"genre_scores_gemma":[0.9975742,0.0008451284,0.0003034297,0.0005884803,0.0001543464,0.00001797252,0.000334531,0.00002711297,0.0001548708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1474076,"threshold_uncertainty_score":0.7212347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004342349189389551,"score_gpt":0.1810874558559207,"score_spread":0.1767451066665312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}