{"id":"W3210441673","doi":"10.1002/eji.202149406","title":"SLAMF7 selectively favors degranulation to promote cytotoxicity in human NK cells","year":2021,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Consejo Nacional de Ciencia y Tecnología; International Development Research Centre","keywords":"Degranulation; Biology; Cell biology; Perforin; Interleukin 21; Lymphokine-activated killer cell; Cell; Immunology; Receptor; T cell; Immune system; CD8; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002180561,0.0002155253,0.0002333384,0.0001632957,0.0001067365,0.0002664138,0.0001030104,0.0002823303,0.002480873],"category_scores_gemma":[0.0002540912,0.00006838047,0.0002202476,0.000108335,0.0001370528,0.0001732394,0.000248827,0.0003127371,0.0006026464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001645048,"about_ca_system_score_gemma":0.0001587344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000291499,"about_ca_topic_score_gemma":0.0003258913,"domain_scores_codex":[0.9997384,0.0000810842,0.00002034864,0.00003397677,0.00004969082,0.00007648974],"domain_scores_gemma":[0.999896,0.00003458007,0.0000120976,0.00001579535,0.00001798324,0.00002356861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001613161,0.00003017099,0.0002568437,0.00003574426,0.000003600546,0.00008285758,0.00001644136,0.00003072111,0.998,0.00006291053,0.00005522517,0.001264295],"study_design_scores_gemma":[0.0000531828,0.0009420604,0.005709269,0.00001280379,0.00002919292,0.001133043,0.00004389123,0.001012016,0.9864009,0.0000757547,0.004581403,0.000006450483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956244,0.001743027,0.001149162,0.00007533204,0.00002563542,0.00003003422,0.0001109797,0.00003463997,0.00120697],"genre_scores_gemma":[0.9980494,0.0003142069,0.0006032528,0.00004069439,0.00001441091,0.0000210869,0.0002308167,0.000005701002,0.0007204804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002480873,"threshold_uncertainty_score":0.008299291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319809952270387,"score_gpt":0.2337177362217375,"score_spread":0.2205196366990336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}