{"id":"W3210443040","doi":"10.1016/j.stemcr.2021.10.004","title":"PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs","year":2021,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"Université Libanaise; Fondation Leducq; Agence Nationale de la Recherche; Institut Français de Bioinformatique","keywords":"PCSK9; Proprotein convertase; Biology; Proprotein Convertases; Cell biology; Degron; Kexin; Regulator; Small hairpin RNA; LDL receptor; Cell growth; RNA interference; Signal transduction; Lipoprotein; Cholesterol; Cell culture; Genetics; Biochemistry; Gene knockdown; Ubiquitin ligase; RNA; Gene; Ubiquitin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009364109,0.0002101159,0.0002043044,0.0002535397,0.0001564642,0.0002530369,0.0001518689,0.0001826632,0.001167439],"category_scores_gemma":[0.00008138099,0.00009602345,0.0002199911,0.0001695164,0.0001922691,0.0001220016,0.0002097545,0.0005343767,0.0004194921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003461454,"about_ca_system_score_gemma":0.0002412063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350394,"about_ca_topic_score_gemma":0.001830461,"domain_scores_codex":[0.9998679,0.00001039629,0.00001765487,0.00002640653,0.00005015295,0.00002739219],"domain_scores_gemma":[0.9999273,0.000009254514,0.00001876513,0.00000985841,0.00001194393,0.00002295076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001224807,0.00002850382,0.0002496077,0.00004601562,0.000005655073,0.00007227753,0.00001957203,0.0001320689,0.996372,0.0002089328,0.0001164358,0.002626455],"study_design_scores_gemma":[0.00001813003,0.00006784469,0.004181291,0.00000758607,0.00001238442,0.0001195503,0.00002207078,0.001020087,0.9909065,0.00005932872,0.003581355,0.000003924335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832797,0.002312398,0.007020048,0.0001215319,0.00006213792,0.00005371304,0.00143373,0.0002731772,0.005443654],"genre_scores_gemma":[0.9897194,0.0008633258,0.002575379,0.00006813181,0.00000881071,0.00005225376,0.000960157,0.00004098625,0.005711557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350394,"threshold_uncertainty_score":0.003905475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005942363315127334,"score_gpt":0.2223610212190238,"score_spread":0.2164186579038965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}