{"id":"W3210549609","doi":"10.1182/blood-2021-146060","title":"Updated Results from CARTITUDE-1: Phase 1b/2Study of Ciltacabtagene Autoleucel, a B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T Cell Therapy, in Patients With Relapsed/Refractory Multiple Myeloma","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Chimeric antigen receptor; Antigen; Medicine; Multiple myeloma; Immunology; Refractory (planetary science); Immunotherapy; Cancer research; Biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003093533,0.0004007182,0.0007686742,0.0002995775,0.00009695485,0.00004209466,0.0002267849,0.0002483115,0.001187461],"category_scores_gemma":[0.0001474936,0.0003495582,0.0001362234,0.00126386,0.0001000416,0.0001767967,0.00008807131,0.0005338151,0.00004843843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001047908,"about_ca_system_score_gemma":0.000492756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006267193,"about_ca_topic_score_gemma":0.0001759245,"domain_scores_codex":[0.9963554,0.000400749,0.0008654362,0.0008688383,0.0009644143,0.00054521],"domain_scores_gemma":[0.9975428,0.0001848619,0.0003834548,0.001006114,0.0006516746,0.0002310917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01148799,0.02446065,0.1350551,0.00004059108,0.0003303233,0.0001349313,0.0018027,0.000007864643,0.8222407,1.282426e-7,0.0005279711,0.003911066],"study_design_scores_gemma":[0.08766352,0.002183835,0.3188298,0.0001046476,0.00006922202,0.000002230066,0.0001567287,0.0001356892,0.5882228,9.688538e-7,0.002359071,0.0002714783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951598,0.001239826,0.000007451617,0.00006794328,0.000168326,0.001566232,0.0004628406,0.0001530604,0.00117454],"genre_scores_gemma":[0.9918526,0.0008199868,0.001737236,0.00007245917,0.0001179916,0.00004206023,0.004002135,0.0001042852,0.001251191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2340179,"threshold_uncertainty_score":0.9998956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458979055036721,"score_gpt":0.2588514183657435,"score_spread":0.2442616278153763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}