{"id":"W3210549609","doi":"10.1182/blood-2021-146060","title":"Updated Results from CARTITUDE-1: Phase 1b/2Study of Ciltacabtagene Autoleucel, a B-Cell Maturation Antigen-Directed Chimeric Antigen Receptor T Cell Therapy, in Patients With Relapsed/Refractory Multiple Myeloma","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Chimeric antigen receptor; Antigen; Medicine; Multiple myeloma; Immunology; Refractory (planetary science); Immunotherapy; Cancer research; Biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006020621,0.0008697656,0.001571961,0.0007123995,0.000260091,0.001169569,0.0007360094,0.0006881256,0.001897317],"category_scores_gemma":[0.004585574,0.000392963,0.001583081,0.001109461,0.0001833942,0.0006342778,0.000617947,0.001111288,0.0003903007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009640312,"about_ca_system_score_gemma":0.001105854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002635467,"about_ca_topic_score_gemma":0.006157189,"domain_scores_codex":[0.9978727,0.0009005021,0.0002638302,0.0002145534,0.0005815137,0.0001669398],"domain_scores_gemma":[0.9933358,0.001743547,0.002354387,0.0005344713,0.001301926,0.0007297447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1895299,0.005395602,0.1906043,0.005282703,0.01389507,0.000939872,0.0007527944,0.00549288,0.05578537,0.0002672442,0.06735234,0.464702],"study_design_scores_gemma":[0.03387554,0.0496614,0.8122616,0.0003723564,0.01510952,0.002447007,0.0001261583,0.001580566,0.01314321,0.000165201,0.07112845,0.0001290039],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8683551,0.04003973,0.002248303,0.002271177,0.0003861292,0.001728839,0.076116,0.0004294036,0.008425415],"genre_scores_gemma":[0.8505046,0.009216304,0.00473568,0.003534731,0.0006948818,0.001174076,0.1269228,0.0001797632,0.003037221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006020621,"threshold_uncertainty_score":0.03184044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458979055036721,"score_gpt":0.2588514183657435,"score_spread":0.2442616278153763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}