{"id":"W3210585415","doi":"10.3390/pharmaceutics13111820","title":"Host Defense Peptide-Mimicking Polymers and Polymeric-Brush-Tethered Host Defense Peptides: Recent Developments, Limitations, and Potential Success","year":2021,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Michael Smith Health Research BC; NanoMedicines Innovation Network","keywords":"Nanotechnology; Broad spectrum; Antimicrobial peptides; Antimicrobial; Polymer brush; Amphiphile; Materials science; Chemistry; Polymer; Combinatorial chemistry; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003604228,0.001018594,0.001972629,0.0003570762,0.0007884955,0.0002510045,0.0003589423,0.0007117764,0.0003939393],"category_scores_gemma":[0.000150599,0.0009785757,0.0003717996,0.0004197844,0.0007230866,0.000261164,0.0005932437,0.001189875,0.0001065042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001493296,"about_ca_system_score_gemma":0.0005844513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001086857,"about_ca_topic_score_gemma":0.00002686331,"domain_scores_codex":[0.9961306,0.0006989866,0.001043763,0.001026627,0.0001186766,0.0009813692],"domain_scores_gemma":[0.9979341,0.0006176428,0.0007280487,0.0003921178,0.0001683666,0.0001597335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000087416,0.0002240054,0.0001163862,0.003789149,0.002425656,0.0001548851,0.00103395,8.945813e-7,0.006412619,0.0001893493,0.002572378,0.9829933],"study_design_scores_gemma":[0.001040981,0.00005248409,0.00003395472,0.003585491,0.002314667,0.001348011,0.00120089,0.000001747251,0.00246331,0.000004718417,0.9868019,0.001151866],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002771358,0.9935974,0.00006178677,0.0001861415,0.00136934,0.0007637303,0.0004476088,0.0001204727,0.0006821493],"genre_scores_gemma":[0.005241938,0.990109,0.0005326287,0.0005766414,0.0001367757,0.00005396384,0.0009482967,0.0001634695,0.002237318],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9842295,"threshold_uncertainty_score":0.9992664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07881157912379261,"score_gpt":0.3306028639708178,"score_spread":0.2517912848470252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}