{"id":"W3210585415","doi":"10.3390/pharmaceutics13111820","title":"Host Defense Peptide-Mimicking Polymers and Polymeric-Brush-Tethered Host Defense Peptides: Recent Developments, Limitations, and Potential Success","year":2021,"lang":"en","type":"review","venue":"Pharmaceutics","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Michael Smith Health Research BC; NanoMedicines Innovation Network","keywords":"Nanotechnology; Broad spectrum; Antimicrobial peptides; Antimicrobial; Polymer brush; Amphiphile; Materials science; Chemistry; Polymer; Combinatorial chemistry; Biology; Microbiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004047582,0.0006640058,0.0007493361,0.001288361,0.0001710358,0.0008758849,0.0004308688,0.0007039137,0.001744488],"category_scores_gemma":[0.0004684301,0.0002430265,0.0002824563,0.00130139,0.0002962807,0.00112193,0.0004283912,0.001198015,0.001066093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003055816,"about_ca_system_score_gemma":0.0005546007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003296665,"about_ca_topic_score_gemma":0.0006960953,"domain_scores_codex":[0.9998726,0.00001726688,0.00001610809,0.00002572768,0.00005126948,0.00001710908],"domain_scores_gemma":[0.9998228,0.00009558005,0.00002595189,0.000004904447,0.00003412532,0.00001671776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000732491,0.00008795217,0.0001768324,0.01573954,0.00005188743,0.0002664851,0.00006307804,0.0003673527,0.01027688,0.004278998,0.008615015,0.9600028],"study_design_scores_gemma":[0.00001180828,0.000207166,0.0006824164,0.001839945,0.00008617667,0.001494437,0.00006483972,0.0001567458,0.004416808,0.001416683,0.9896011,0.00002174437],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004388322,0.9981725,0.0001817203,0.0001143069,0.0001178129,0.000003418934,0.00001052483,0.00000576974,0.0009550873],"genre_scores_gemma":[0.001763219,0.9968084,0.0003610718,0.0001301058,0.0001105225,0.000006583208,0.00002383508,0.000001827826,0.0007944899],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001744488,"threshold_uncertainty_score":0.005835891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07881157912379261,"score_gpt":0.3306028639708178,"score_spread":0.2517912848470252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}