{"id":"W3210600262","doi":"10.1016/j.jbc.2021.101351","title":"Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Innovative Medicines Initiative; Ministry of Education of the People's Republic of China; Genentech; Xi'an Eurasia University; National Natural Science Foundation of China; Wellcome Trust; Genome Canada; Ontario Genomics Institute; Central China Normal University; Takeda Pharmaceutical Company; European Federation of Pharmaceutical Industries and Associations; Janssen Pharmaceuticals; Merck KGaA; Boehringer Ingelheim; Pfizer","keywords":"DNA methylation; Methylation; DNA; RNA; Basis (linear algebra); Computational biology; Genetics; Biology; Chemistry; Biochemistry; Cell biology; Molecular biology; Gene; Gene expression; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002803207,0.00009841274,0.0002700985,0.00003120476,0.00001548265,0.000004317234,0.0001690917,0.0002411243,0.00009446438],"category_scores_gemma":[0.000444083,0.0000614067,0.0001675332,0.0002560116,0.00007367951,0.000004666439,0.0001160117,0.0001493075,9.106935e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006056528,"about_ca_system_score_gemma":0.0002043043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006914628,"about_ca_topic_score_gemma":0.00001230155,"domain_scores_codex":[0.9988399,0.00008326059,0.0006135558,0.0001424412,0.0001858455,0.0001350655],"domain_scores_gemma":[0.9988877,0.00003885467,0.0006060141,0.0001772243,0.0002319417,0.0000582576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003530648,0.00003563891,0.01141533,0.00004078204,0.00005406191,0.000002205794,0.00004854252,0.001013611,0.9853338,0.000002829021,0.00002195463,0.001678157],"study_design_scores_gemma":[0.000560624,0.0001540735,0.04880039,0.00007222685,0.00001567779,0.00003008176,0.0002815999,0.00001254496,0.9497815,0.00008397755,0.0001407795,0.00006652289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990452,0.0004633962,0.00009698921,0.000113523,0.00009131309,0.00006245267,0.00002876105,7.93225e-7,0.00009759799],"genre_scores_gemma":[0.9989328,0.0001204622,0.000774223,0.00001296273,0.00008946516,0.000001039368,0.00001693402,0.000005342551,0.00004671838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03738506,"threshold_uncertainty_score":0.2504092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754827894640741,"score_gpt":0.2709012150883874,"score_spread":0.25335293614198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}