{"id":"W3210600262","doi":"10.1016/j.jbc.2021.101351","title":"Structural basis of the TAM domain of BAZ2A in binding to DNA or RNA independent of methylation status","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Innovative Medicines Initiative; Ministry of Education of the People's Republic of China; Genentech; Xi'an Eurasia University; National Natural Science Foundation of China; Wellcome Trust; Genome Canada; Ontario Genomics Institute; Central China Normal University; Takeda Pharmaceutical Company; European Federation of Pharmaceutical Industries and Associations; Janssen Pharmaceuticals; Merck KGaA; Boehringer Ingelheim; Pfizer","keywords":"DNA methylation; Methylation; DNA; RNA; Basis (linear algebra); Computational biology; Genetics; Biology; Chemistry; Biochemistry; Cell biology; Molecular biology; Gene; Gene expression; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039354,0.0003408345,0.000236048,0.0001502509,0.0002218166,0.0001656172,0.0004167544,0.0004223454,0.001302325],"category_scores_gemma":[0.0001477436,0.0001650204,0.000392679,0.00009641072,0.0002753565,0.0001464214,0.0002363676,0.0004193804,0.0006899803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002137705,"about_ca_system_score_gemma":0.0001433197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006037027,"about_ca_topic_score_gemma":0.0006845004,"domain_scores_codex":[0.9998919,0.00001979348,0.000006108098,0.00002938647,0.00003144763,0.00002144376],"domain_scores_gemma":[0.9999149,0.00001662397,0.00002180538,0.000009448615,0.00001025283,0.00002694603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001163325,0.00002693493,0.0004422666,0.0000314957,0.000007935825,0.0001046399,0.00001194471,0.0002144735,0.997933,0.0002522223,0.00004009719,0.0008185784],"study_design_scores_gemma":[0.00005403349,0.0001694051,0.01471026,0.00000728631,0.00002283687,0.0007713159,0.00004123219,0.008437997,0.9714434,0.0002654078,0.004062477,0.00001437146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892285,0.0007558108,0.008040843,0.0001272095,0.00002903567,0.00003053366,0.0002182362,0.0001212037,0.001448598],"genre_scores_gemma":[0.9967248,0.0001254989,0.001853247,0.00006173071,0.000007331992,0.00002059303,0.0003316888,0.00001419554,0.000860787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001302325,"threshold_uncertainty_score":0.004356742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01754827894640741,"score_gpt":0.2709012150883874,"score_spread":0.25335293614198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}