{"id":"W3210614127","doi":"10.1101/2021.10.22.465428","title":"Loss of epigenetic regulation disrupts lineage integrity, reactivates multipotency and promotes breast cancer","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"European Regional Development Fund; Canadian Institutes of Health Research; Terry Fox Research Institute; University of Toronto; National Cancer Institute; National Institutes of Health; Generalitat de Catalunya; Centres de Recerca de Catalunya; Breast Cancer Research Foundation; Susan G. Komen for the Cure","keywords":"Epigenetics; Biology; Carcinogenesis; Breast cancer; Cancer research; CRISPR; Lineage (genetic); Epigenomics; Somatic cell; Cancer; DNA methylation; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001883124,0.0002030212,0.0001684745,0.0002223708,0.0001286872,0.0003405707,0.000179901,0.0002560806,0.001798286],"category_scores_gemma":[0.0001239239,0.0001285644,0.0002024475,0.0000987131,0.0002269295,0.0001424408,0.0003810225,0.0005545642,0.0003268609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448843,"about_ca_system_score_gemma":0.0001731265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002812267,"about_ca_topic_score_gemma":0.0005244496,"domain_scores_codex":[0.9997607,0.00003395187,0.00002419944,0.00005010914,0.00007984525,0.00005122343],"domain_scores_gemma":[0.9998572,0.0000184624,0.0000532891,0.00002873386,0.00001195086,0.00003043244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003085897,0.00001734468,0.0004679668,0.0000143524,0.000005858162,0.00003953372,0.000005541189,0.00005105993,0.9982322,0.0001215034,0.00004298795,0.0009709748],"study_design_scores_gemma":[0.000007310336,0.0002034704,0.007053223,0.000004663309,0.00001591404,0.0003614642,0.00002420573,0.001296115,0.9879937,0.00008188434,0.002954639,0.000003395365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920441,0.000796728,0.004326436,0.0001602086,0.00003125525,0.00002582113,0.0003548643,0.0002184699,0.002042119],"genre_scores_gemma":[0.9966152,0.000261,0.001024375,0.0000589284,0.000004104994,0.00001314263,0.0002095013,0.00001646085,0.001797203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001798286,"threshold_uncertainty_score":0.006015837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01191037244010468,"score_gpt":0.2460600359421257,"score_spread":0.234149663502021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}