{"id":"W3210654350","doi":"10.3389/fimmu.2021.768957","title":"Mechanisms of Immune Checkpoint Inhibitor-Mediated Colitis","year":2021,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Immune system; Colitis; Immunology; Medicine; Colorectal cancer; Immune checkpoint; Adverse effect; Cancer; Biology; Bioinformatics; Cancer research; Immunotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003202363,0.0006021486,0.0008296655,0.001158775,0.0001849891,0.0007851371,0.0005420679,0.0007119855,0.002945607],"category_scores_gemma":[0.0003205787,0.0001626213,0.0004835597,0.0006067829,0.0003139922,0.000677396,0.0004585281,0.001313092,0.001340045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004214961,"about_ca_system_score_gemma":0.0005835273,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003821971,"about_ca_topic_score_gemma":0.0007971392,"domain_scores_codex":[0.999861,0.00002504439,0.00001776164,0.00002298046,0.00005476298,0.00001851636],"domain_scores_gemma":[0.9998837,0.0000412814,0.00002790244,0.0000039257,0.00002890665,0.00001421329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001548331,0.00008691888,0.0002520739,0.02130798,0.0001246996,0.0002718746,0.00005236655,0.0004631787,0.005821909,0.006976916,0.02744421,0.9370431],"study_design_scores_gemma":[0.00004217005,0.0002330779,0.001348522,0.004314749,0.0001183918,0.00194543,0.00003692557,0.0001358567,0.001673143,0.003493267,0.9866411,0.00001735195],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002828528,0.9973683,0.0001886921,0.000358186,0.0002013172,0.000009527845,0.00003451068,0.00001288181,0.001543827],"genre_scores_gemma":[0.001886517,0.9967352,0.0001536201,0.0002511531,0.0001479693,0.00001257035,0.000048211,0.000001536841,0.000763224],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002945607,"threshold_uncertainty_score":0.009854019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849236876837089,"score_gpt":0.2821279927271378,"score_spread":0.2636356239587669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}