{"id":"W3210671233","doi":"10.1126/sciadv.abj1561","title":"DNA methylation at a nutritionally sensitive region of the <i>PAX8</i> gene is associated with thyroid volume and function in Gambian children","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"National Institute of Environmental Health Sciences; Medical Research Council; University of Oxford; Academy of Medical Sciences; London School of Hygiene and Tropical Medicine","keywords":"PAX8; DNA methylation; Gene; Methylation; Thyroid function; Function (biology); Epigenetics; DNA; Biology; Thyroid; Genetics; Medicine; Physiology; Endocrinology; Gene expression; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002316998,0.00006738793,0.00007732571,0.00003412631,0.0001328065,0.0000150104,0.00006349036,0.00004483011,0.000001613846],"category_scores_gemma":[0.000123753,0.00005243073,0.00002335223,0.0004010426,0.0002672731,0.00002095375,0.00006576542,0.00003800295,2.522718e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002580032,"about_ca_system_score_gemma":0.0001011949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008396855,"about_ca_topic_score_gemma":0.0002739916,"domain_scores_codex":[0.9992097,0.00005983473,0.0001169805,0.0002855899,0.0002093477,0.0001185412],"domain_scores_gemma":[0.9994806,0.00001284952,0.0001161059,0.0001440324,0.0002193576,0.00002702133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002833271,0.00002320009,0.05654418,0.00000226357,0.000006325801,9.132681e-7,0.00005316334,0.0001891105,0.9416827,0.0000091942,0.000009987633,0.001450629],"study_design_scores_gemma":[0.0002437795,0.00009704273,0.2929128,0.00001767875,0.000007035813,0.000007272055,0.00003129138,0.00005020617,0.7061141,0.0002784794,0.0001848245,0.00005544368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964628,0.002439811,0.0005176294,0.0002500541,0.00005662537,0.0001065435,0.00001456636,0.000002330714,0.0001496944],"genre_scores_gemma":[0.9990308,0.0002770832,0.0002381297,0.0001160114,0.00002430286,0.000004061792,0.00004519089,0.00000442192,0.0002599413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2363687,"threshold_uncertainty_score":0.2138063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006283197038159047,"score_gpt":0.2243493072428817,"score_spread":0.2180661102047227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}