{"id":"W3210673974","doi":"10.1093/schbul/sbab132","title":"Exploring the Relationship Between Schizophrenia and Cardiovascular Disease: A Genetic Correlation and Multivariable Mendelian Randomization Study","year":2021,"lang":"en","type":"article","venue":"Schizophrenia Bulletin","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Medical Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; University Hospitals Bristol NHS Foundation Trust; Stichting Volksbond Rotterdam; University of Bristol; National Institute for Health and Care Research; National Alliance for Research on Schizophrenia and Depression","keywords":"Mendelian randomization; Schizophrenia (object-oriented programming); Multivariable calculus; Correlation; Disease; Mendelian inheritance; Medicine; Genetic correlation; Psychiatry; Psychology; Genetics; Biology; Internal medicine; Genetic variants; Genetic variation; Gene; Mathematics; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01109806,0.0006418762,0.000773654,0.0009232915,0.0006810984,0.0006105714,0.0008953682,0.0007517966,0.002025543],"category_scores_gemma":[0.02561392,0.000479717,0.001849381,0.001482029,0.0004294105,0.0003642468,0.000718284,0.0008291237,0.0001770886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003575179,"about_ca_system_score_gemma":0.0008778685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007359633,"about_ca_topic_score_gemma":0.004337068,"domain_scores_codex":[0.9865487,0.01031398,0.0004721093,0.001523535,0.0007855604,0.0003561463],"domain_scores_gemma":[0.9870673,0.007611122,0.001651681,0.002670863,0.0005949842,0.0004041467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.004771147,0.0003600242,0.9599301,0.00009931205,0.006874807,0.001377112,0.0006946398,0.002714705,0.003756781,0.002866203,0.001237891,0.01531734],"study_design_scores_gemma":[0.001492201,0.004762784,0.881128,0.00005049782,0.005870657,0.003652774,0.0004728396,0.09109861,0.001199987,0.006747342,0.003390341,0.0001339089],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785277,0.0002737636,0.01994156,0.0002271593,0.00003043709,0.0001253794,0.0004493569,0.00008242472,0.0003420847],"genre_scores_gemma":[0.9915063,0.00005827819,0.007854987,0.00006226453,0.00001821664,0.0000867389,0.0001990968,0.00001882229,0.0001953893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01109806,"threshold_uncertainty_score":0.05869281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04477753074024456,"score_gpt":0.2497186365337722,"score_spread":0.2049411057935277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}