{"id":"W3210700573","doi":"10.1002/ardp.202100300","title":"2‐Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors","year":2021,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; Jürgen Manchot Stiftung","keywords":"Allosteric regulation; Chemistry; Pharmacology; Stereochemistry; Enzyme; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001120958,0.0002939123,0.000290201,0.0001538583,0.00008225828,0.0001791499,0.0001831059,0.000272527,0.00159427],"category_scores_gemma":[0.00009626264,0.00008819983,0.0001750612,0.0001878814,0.00008812954,0.0001301718,0.00008847233,0.0003251868,0.0003747922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002356475,"about_ca_system_score_gemma":0.0001251071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005860573,"about_ca_topic_score_gemma":0.001529992,"domain_scores_codex":[0.9999306,0.00001855473,0.000005440093,0.00001423506,0.00001261169,0.00001844395],"domain_scores_gemma":[0.9999605,0.000008002937,0.00001124469,0.000004195377,0.000006583011,0.000009542448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001131022,0.0002150537,0.0004098421,0.0004703709,0.00005144183,0.0004051175,0.0000579099,0.002077294,0.9710821,0.0005837259,0.0008625643,0.02265359],"study_design_scores_gemma":[0.0007079284,0.00996661,0.007788208,0.00008656165,0.000187722,0.002494357,0.0000604198,0.005689051,0.9231883,0.0002209725,0.04955759,0.00005221493],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9318581,0.05262395,0.004986096,0.0002490112,0.0002098325,0.0001572568,0.001033108,0.000142779,0.008739844],"genre_scores_gemma":[0.9816678,0.01036692,0.002988014,0.0001721637,0.00005152581,0.00006809455,0.0006304637,0.00001258609,0.004042443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00159427,"threshold_uncertainty_score":0.005333364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01279757340505835,"score_gpt":0.2580068073348385,"score_spread":0.2452092339297801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}