{"id":"W3210700573","doi":"10.1002/ardp.202100300","title":"2‐Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors","year":2021,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Deutsche Forschungsgemeinschaft; Natural Sciences and Engineering Research Council of Canada; Jürgen Manchot Stiftung","keywords":"Allosteric regulation; Chemistry; Pharmacology; Stereochemistry; Enzyme; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008382455,0.0002152062,0.0001625524,0.0000553594,0.0001313432,0.00003801963,0.0001882604,0.0000651048,0.0002147419],"category_scores_gemma":[0.000094699,0.0002112367,0.0001268636,0.000231337,0.00009876813,0.00001018928,0.0002242221,0.0001555614,0.00005153797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008476392,"about_ca_system_score_gemma":0.0001222232,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008405726,"about_ca_topic_score_gemma":0.00000274266,"domain_scores_codex":[0.9987037,0.0000995871,0.0002404946,0.0004538043,0.0001634693,0.0003389967],"domain_scores_gemma":[0.9993278,0.0000295436,0.00006607378,0.0003393923,0.00008331415,0.0001538256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006166493,0.0001500156,0.001010144,0.00002411454,0.0001361781,0.0001733831,0.0001900423,0.0002281715,0.978106,0.0000744258,0.01883591,0.001009991],"study_design_scores_gemma":[0.001162646,0.00005864976,0.0007354206,0.00002502718,0.00004168103,0.0001434765,0.00007250888,0.0002876736,0.945705,0.0001423592,0.05130907,0.0003164988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888244,0.003585158,0.00297427,0.0005508552,0.0002665669,0.0001113023,0.00002175845,0.00004253554,0.003623134],"genre_scores_gemma":[0.9954247,0.0002821879,0.001477008,0.001172084,0.0006503427,0.00001130277,0.0003662627,0.0000395261,0.0005765329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03247315,"threshold_uncertainty_score":0.8613981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01279757340505835,"score_gpt":0.2580068073348385,"score_spread":0.2452092339297801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}