{"id":"W3210719971","doi":"10.1016/j.nicl.2021.102864","title":"Accelerated brain aging in major depressive disorder and antidepressant treatment response: A CAN-BIND report","year":2021,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Centre for Addiction and Mental Health; University of British Columbia; St. Joseph’s Healthcare Hamilton; Baycrest Hospital; University of Calgary; University Health Network; University of Toronto; Queen's University; McMaster University","funders":"Janssen Pharmaceuticals; Allergan; H. Lundbeck A/S; Lundbeckfonden; Sunovion; Canadian Institutes of Health Research; Michael Smith Health Research BC; Mitacs; Healthy Minds Canada; Ontario Mental Health Foundation; Ontario Brain Institute; Pfizer","keywords":"Escitalopram; Major depressive disorder; Aripiprazole; Antidepressant; Depression (economics); Late life depression; Psychology; Internal medicine; Rating scale; Medicine; Psychiatry; Hippocampus; Amygdala; Cognition; Schizophrenia (object-oriented programming); Developmental psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007961387,0.0002670251,0.0005011167,0.0001137278,0.0002514529,0.000128169,0.0001425747,0.0001053156,0.00004754845],"category_scores_gemma":[0.08744149,0.0002452581,0.000128331,0.0004745081,0.000346538,0.0001870623,0.0003589648,0.0004349591,0.00001291641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005897902,"about_ca_system_score_gemma":0.0002836494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001073239,"about_ca_topic_score_gemma":0.000449568,"domain_scores_codex":[0.9952706,0.001720665,0.0007214931,0.001581378,0.0003047556,0.0004010776],"domain_scores_gemma":[0.9727786,0.02617219,0.0001897026,0.0006319566,0.00009062242,0.0001368804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001183322,0.001094273,0.8068814,0.00001979309,0.00003835867,0.04510481,0.0002247201,0.00005377725,0.1367179,0.00004296747,0.00191924,0.006719464],"study_design_scores_gemma":[0.003889292,0.0003729036,0.9504868,0.00003914427,0.00002868074,0.001415187,0.00008202451,0.0006285881,0.03029935,0.0001205433,0.01234244,0.0002949934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9554762,0.0002495315,0.00003456521,0.04295893,0.0004628766,0.0003202892,0.00003934703,0.00008527442,0.0003730292],"genre_scores_gemma":[0.9912366,0.0002081033,0.00009367258,0.006115825,0.0001078431,0.00005757442,0.000006097871,0.00003808162,0.002136177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1436055,"threshold_uncertainty_score":0.9999999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1099288669248397,"score_gpt":0.3901672285283161,"score_spread":0.2802383616034764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}