{"id":"W3210772601","doi":"10.1172/jci.insight.148510","title":"Nociceptor neurons promote IgE class switch in B cells","year":2021,"lang":"en","type":"article","venue":"JCI Insight","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; American Academy of Otolaryngic Allergy Foundation; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Broad Institute; Fondation Brain Canada; Canadian Institutes of Health Research","keywords":"Nociceptor; Immunoglobulin E; Inflammation; Immunology; Immune system; Allergic inflammation; Acquired immune system; Antibody; Innate immune system; Neuroscience; Cell biology; Medicine; Biology; Receptor; Nociception; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001620127,0.0003136954,0.0002216642,0.0002492805,0.0001202374,0.0002831886,0.0002424117,0.0003443737,0.002227476],"category_scores_gemma":[0.0001549194,0.0001596141,0.0002278244,0.0000700131,0.000228238,0.0002153363,0.000383184,0.0009192436,0.0006216342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000180276,"about_ca_system_score_gemma":0.0001362746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000328085,"about_ca_topic_score_gemma":0.0003891462,"domain_scores_codex":[0.9998171,0.00002688739,0.00001302751,0.000033775,0.00003934789,0.00007001767],"domain_scores_gemma":[0.9998965,0.00002033006,0.00002482287,0.00001317322,0.00001320059,0.00003187903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003732524,0.00001516959,0.00008345414,0.00001825223,0.000001925741,0.00004141343,0.000008624185,0.00001780864,0.998887,0.00007287182,0.00002087385,0.000795341],"study_design_scores_gemma":[0.00005926386,0.0003072841,0.01179353,0.000021677,0.00002051672,0.0003920461,0.00006426183,0.0008066691,0.9834092,0.0002259705,0.002895621,0.000003886762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915297,0.002247557,0.002200624,0.0002048512,0.00005730919,0.00004393697,0.0001987375,0.0001118674,0.003405439],"genre_scores_gemma":[0.9948645,0.0009212743,0.001202817,0.0001222554,0.00002448363,0.00003929633,0.0001652592,0.00002331977,0.002636857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002227476,"threshold_uncertainty_score":0.007451653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470964381194395,"score_gpt":0.2600553333144329,"score_spread":0.245345689502489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}