{"id":"W3210787730","doi":"10.2217/imt-2021-0068","title":"Association Between PD-L1 Inhibitor, Tumor Site and Adverse Events of Potential Immune Etiology Within the US FDA Adverse Event Reporting System","year":2021,"lang":"en","type":"article","venue":"Immunotherapy","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Adverse effect; Adverse Event Reporting System; Common Terminology Criteria for Adverse Events; Internal medicine; Ipilimumab; Oncology; Cancer; Immunotherapy; Nivolumab; Etiology; MedDRA; Kidney cancer; Pharmacovigilance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004008269,0.0001701626,0.0003373422,0.001676499,0.0002054503,0.0005473614,0.0002519349,0.0003176108,0.002628384],"category_scores_gemma":[0.01988111,0.0001058396,0.000724467,0.001951347,0.0002118169,0.000479787,0.0003920031,0.000544233,0.0001872017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000419846,"about_ca_system_score_gemma":0.0005565927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001909507,"about_ca_topic_score_gemma":0.00211023,"domain_scores_codex":[0.9952663,0.001527886,0.001316307,0.0005278708,0.001074899,0.0002866149],"domain_scores_gemma":[0.938675,0.01852849,0.03815835,0.001186917,0.002667079,0.0007840861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001971428,0.00002145522,0.9960098,0.00004298894,0.0001162192,0.00004721871,0.00000917304,0.0001292528,0.0001667097,0.000021698,0.000176159,0.003062134],"study_design_scores_gemma":[0.00001923154,0.0001877983,0.996744,0.00003794255,0.00009608098,0.0008286142,0.00004159828,0.0008192754,0.0002936326,0.00003872933,0.000885709,0.000007322114],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986747,0.004427633,0.001794266,0.0004978869,0.00003005825,0.00009826825,0.003940257,0.0000473356,0.002417193],"genre_scores_gemma":[0.9978986,0.0003422044,0.0005208807,0.0001025059,0.00003311213,0.00002916792,0.0009102712,0.000004372867,0.0001589869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004008269,"threshold_uncertainty_score":0.02119797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01024507710060336,"score_gpt":0.2668065637972968,"score_spread":0.2565614866966934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}