{"id":"W3210822175","doi":"10.14309/01.ajg.0000776548.94565.6c","title":"S754 Risankizumab as Induction Therapy in Patients with Moderately to Severely Active Crohn’s Disease Who Failed 1 vs >1 Prior Biologic Treatment: Results From the MOTIVATE Study","year":2021,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Robarts Clinical Trials; University of Calgary","funders":"","keywords":"Medicine; Ustekinumab; Crohn's disease; Internal medicine; Clinical endpoint; Gastroenterology; Placebo; Randomization; Population; Randomized controlled trial; Intention-to-treat analysis; Inflammatory bowel disease; Disease; Infliximab; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009110012,0.0003995483,0.001419974,0.0001604063,0.0001828011,0.0005268614,0.0002975888,0.0005568001,0.001662028],"category_scores_gemma":[0.0007273663,0.0001917857,0.00121654,0.0002422776,0.0002935987,0.0003676048,0.00027277,0.0007903919,0.0003445277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005235631,"about_ca_system_score_gemma":0.0006314652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009037877,"about_ca_topic_score_gemma":0.003688272,"domain_scores_codex":[0.9996488,0.0001826832,0.00002303926,0.00004691957,0.00004049942,0.00005808958],"domain_scores_gemma":[0.9995571,0.00009186351,0.0001298568,0.00003083299,0.00002547586,0.0001648641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7637742,0.01298411,0.06025814,0.001238541,0.003338496,0.0002302912,0.0002573519,0.001144072,0.009972493,0.0002783872,0.005143867,0.1413801],"study_design_scores_gemma":[0.380502,0.3228775,0.2817302,0.0002233836,0.002993952,0.0004162361,0.0001605361,0.001602385,0.001214524,0.0002682066,0.007946788,0.00006423381],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995015,0.003021444,0.00005687353,0.0001953115,0.00003971825,0.0001392814,0.000407342,0.00001559151,0.001109401],"genre_scores_gemma":[0.9967422,0.00102308,0.0001908551,0.0003694583,0.0001058201,0.0001382686,0.0008678145,0.000004140851,0.0005583745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662028,"threshold_uncertainty_score":0.005559981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00888594975945961,"score_gpt":0.2342847298807297,"score_spread":0.2253987801212701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}