{"id":"W3210878663","doi":"10.1186/s13195-021-00921-5","title":"The apolipoprotein receptor LRP3 compromises APP levels","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Universitat de Barcelona; Ministerio de Economía y Competitividad; Universität Wien; Medizinische Universität Wien; Georgetown University; Université de Sherbrooke; European Regional Development Fund; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Generalitat Valenciana; University of Nebraska Medical Center","keywords":"Reelin; Low-density lipoprotein receptor-related protein 8; Western blot; Amyloid precursor protein; Receptor; Blot; Biology; Molecular biology; Internal medicine; Endocrinology; Cell biology; Alzheimer's disease; Medicine; Lipoprotein; Genetics; Gene; Very low-density lipoprotein; Cholesterol","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002019281,0.0004127938,0.0003194131,0.0001836262,0.0001999117,0.0003968412,0.000216989,0.0005168114,0.001719538],"category_scores_gemma":[0.0002396919,0.0001271033,0.0003319634,0.0001493292,0.000238451,0.0001690596,0.0002276303,0.00041182,0.0006289821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002921406,"about_ca_system_score_gemma":0.0002187045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009573419,"about_ca_topic_score_gemma":0.001076799,"domain_scores_codex":[0.9997908,0.00002910101,0.00001878705,0.00003496873,0.00004757974,0.00007875479],"domain_scores_gemma":[0.9998624,0.00002261684,0.00003808409,0.0000185505,0.00002305465,0.00003519775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002246124,0.00001833225,0.0004642569,0.00002130874,0.000009216945,0.0002763866,0.00001547693,0.0000105141,0.9982491,0.00003582031,0.00005825544,0.0006168654],"study_design_scores_gemma":[0.00004411936,0.0008683086,0.02479076,0.00001445266,0.00006850396,0.004114895,0.0001578041,0.0008783563,0.9641023,0.0001517052,0.004797165,0.00001160932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967124,0.0006608276,0.001166785,0.0001362,0.00003736153,0.00002185306,0.0002286114,0.0001198382,0.0009161348],"genre_scores_gemma":[0.9975067,0.0002496564,0.0006104766,0.00008607076,0.00001131352,0.00002954726,0.000271515,0.0000286235,0.001206071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001719538,"threshold_uncertainty_score":0.005752444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1860297527875598,"score_gpt":0.4255492418361751,"score_spread":0.2395194890486153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}