{"id":"W3210879889","doi":"10.1371/journal.pntd.0009899","title":"Identification of novel proteins and mRNAs differentially bound to the Leishmania Poly(A) Binding Proteins reveals a direct association between PABP1, the RNA-binding protein RBP23 and mRNAs encoding ribosomal proteins","year":2021,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Foundation for Scientific and Technological Development in Health; Fundação Oswaldo Cruz; Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Biology; Poly(A)-binding protein; RNA-binding protein; Immunoprecipitation; Ribosomal protein; Cell biology; RNA; Translation (biology); Molecular biology; Messenger RNA; Ribosome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006387749,0.0003663033,0.0002221419,0.0003331854,0.0001780681,0.0003379459,0.000175796,0.0003017158,0.001420199],"category_scores_gemma":[0.0001612408,0.000171994,0.0003311283,0.0002835752,0.0001887661,0.0001583692,0.0002214164,0.0004393359,0.0006954548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002045052,"about_ca_system_score_gemma":0.0001407527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004519349,"about_ca_topic_score_gemma":0.000705126,"domain_scores_codex":[0.9998955,0.000007172403,0.000005122356,0.00004388696,0.00002280135,0.0000255523],"domain_scores_gemma":[0.99989,0.00002164043,0.00003360973,0.000009353937,0.00001153404,0.00003385741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006728341,0.000009065804,0.0006575237,0.00004156619,0.000009582121,0.0001501729,0.0000141774,0.00001668861,0.9983221,0.00003806228,0.00003755629,0.0006362339],"study_design_scores_gemma":[0.00002272932,0.000356885,0.1466966,0.00002290112,0.00009044258,0.004402396,0.000186662,0.001839488,0.8388987,0.0001945112,0.007266428,0.00002237433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923988,0.002488461,0.002763555,0.000126972,0.00002364168,0.00001487273,0.001123062,0.00008653354,0.0009740846],"genre_scores_gemma":[0.9896276,0.001008991,0.003589161,0.0002169835,0.00002673961,0.00003991267,0.002579007,0.00004537529,0.002866199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001420199,"threshold_uncertainty_score":0.004751027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01617599690746593,"score_gpt":0.237599129434313,"score_spread":0.2214231325268471,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}