{"id":"W3210901280","doi":"10.1016/j.xpro.2021.100920","title":"In vitro evaluation of CAR-T cells in patient-derived glioblastoma models","year":2021,"lang":"en","type":"article","venue":"STAR Protocols","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; McMaster University","keywords":"Chimeric antigen receptor; Glioblastoma; In vitro; Cancer research; Immunotherapy; Protocol (science); Cytotoxicity; Medicine; Cancer; Biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001391261,0.0008919065,0.001145912,0.0005838719,0.0003629175,0.0008155253,0.0006099795,0.0006968931,0.003038731],"category_scores_gemma":[0.0003775015,0.0003494396,0.0005807752,0.0005362575,0.0002516084,0.0003084322,0.0003121694,0.001754696,0.00214466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006912447,"about_ca_system_score_gemma":0.0008166941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002501794,"about_ca_topic_score_gemma":0.003897701,"domain_scores_codex":[0.9989915,0.0003240939,0.0001223423,0.0001329153,0.0002733262,0.0001558284],"domain_scores_gemma":[0.9997423,0.00005395673,0.00003144667,0.00005237098,0.00007556156,0.00004435466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00134967,0.001446644,0.0007277989,0.0006833906,0.00008641486,0.0004121644,0.0003082015,0.002245645,0.9788616,0.001060686,0.003754648,0.009063057],"study_design_scores_gemma":[0.0002224022,0.005678067,0.002287467,0.00005902398,0.0001931728,0.0008090697,0.0001084327,0.005106275,0.9691955,0.0002556191,0.01605736,0.00002762296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8693081,0.0153508,0.07333007,0.001139224,0.001113558,0.003566748,0.01616398,0.001859816,0.01816772],"genre_scores_gemma":[0.9237801,0.009049729,0.03763081,0.0005726536,0.000149978,0.004154256,0.01404917,0.0002198307,0.01039359],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.003038731,"threshold_uncertainty_score":0.01016557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06394935725016467,"score_gpt":0.3781126191101677,"score_spread":0.3141632618600031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}