{"id":"W3210919302","doi":"10.1016/bs.mcb.2021.06.018","title":"Identifying Plasmodium falciparum receptor activation using bioluminescence resonance energy transfer (BRET)-based biosensors in HEK293 cells","year":2021,"lang":"en","type":"article","venue":"Methods in cell biology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal","funders":"","keywords":"Multicellular organism; G protein-coupled receptor; Biology; Organism; Plasmodium falciparum; Computational biology; Protozoa; Bioluminescence; Model organism; Identification (biology); Receptor; Malaria; Cell; Gene; Genetics; Ecology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009113649,0.000276267,0.0003892281,0.0001917944,0.00007370611,0.00002597643,0.0002369879,0.0005435689,0.0001144133],"category_scores_gemma":[0.0001316285,0.000291661,0.0001319736,0.0004839364,0.00009546737,0.000009225637,0.00008364755,0.0002189191,0.00000239655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007044421,"about_ca_system_score_gemma":0.0001707391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002238269,"about_ca_topic_score_gemma":0.0001113294,"domain_scores_codex":[0.996758,0.001266411,0.0005296412,0.0008332664,0.00008827526,0.0005243979],"domain_scores_gemma":[0.9992377,0.0001473244,0.00009290702,0.0003647377,0.00008775901,0.00006959237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000107216,0.00009051194,0.0007623353,0.00003241259,0.00000728877,0.000005441812,0.00005434989,0.0008014638,0.9927215,0.0001416175,0.00001977191,0.005256091],"study_design_scores_gemma":[0.0007313768,0.00009867187,0.00005442601,0.00006660381,0.000006292451,0.000001995926,0.0001408733,0.003015597,0.9827223,0.000193256,0.01263439,0.0003342608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5800411,0.0008909349,0.4181662,0.00004310997,0.0005880981,0.00009844448,0.0000151059,0.00001055446,0.0001465045],"genre_scores_gemma":[0.7124709,0.0004088851,0.2862225,0.000322117,0.0001358317,0.00002759415,0.0001501765,0.00004071466,0.0002212792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1324299,"threshold_uncertainty_score":0.9999536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04538162992519281,"score_gpt":0.3403253303923478,"score_spread":0.294943700467155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}