{"id":"W3210920430","doi":"10.1093/nar/gkab965","title":"Homologous recombination-mediated irreversible genome damage underlies telomere-induced senescence","year":2021,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Jewish General Hospital; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Mitacs; Canadian Institutes of Health Research; Université de Montréal; Institute of Cancer Research; Institut Du Cancer de Montréal; McGill University","keywords":"Telomere; Senescence; Genome instability; Biology; Homologous recombination; DNA damage; Telomerase; RAD51; Mitosis; Cell biology; Chromosome instability; DNA repair; Cell cycle checkpoint; Genetics; Cell cycle; DNA; Cell; Gene; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000215454,0.000289328,0.0001855259,0.0001942521,0.000126064,0.0002255722,0.0001695371,0.0002974941,0.0007095927],"category_scores_gemma":[0.0001848702,0.0001053032,0.000188892,0.0000866233,0.0002555504,0.0001879665,0.0002600568,0.0003251357,0.0002355177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002250553,"about_ca_system_score_gemma":0.0001736277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000158192,"about_ca_topic_score_gemma":0.0001755136,"domain_scores_codex":[0.9999008,0.00001794735,0.000008369534,0.0000240371,0.00002424365,0.00002463643],"domain_scores_gemma":[0.9998786,0.00001607288,0.00004970481,0.00002599825,0.00001027596,0.00001930995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007636163,0.0000213715,0.001621894,0.00005623368,0.00001124999,0.0003607427,0.0000385195,0.0001869019,0.992657,0.0006500954,0.0000396352,0.004280007],"study_design_scores_gemma":[0.00002001659,0.001087267,0.03910027,0.00001843951,0.00004539022,0.007042303,0.0000903457,0.002389427,0.9437085,0.001550148,0.0049342,0.00001367766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797757,0.008052521,0.009866199,0.0001196751,0.00002451736,0.00002892087,0.00009362314,0.0001395552,0.001899222],"genre_scores_gemma":[0.9977862,0.001069981,0.0004821562,0.00001430756,0.00000768936,0.000005982698,0.00005417997,0.000003160177,0.000576245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007095927,"threshold_uncertainty_score":0.002373815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0800175725222688,"score_gpt":0.3553728719378602,"score_spread":0.2753552994155914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}