{"id":"W3210922155","doi":"10.14309/01.ajg.0000776508.24654.5b","title":"S744 Risankizumab Induction Therapy Provides Early Symptom Improvements in Abdominal Pain and Stool Frequency in Patients With Moderate to Severe Crohn’s Disease: Results From Two Phase 3 Induction Studies","year":2021,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Placebo; Internal medicine; Crohn's disease; Abdominal pain; Gastroenterology; Clinical trial; Quality of life (healthcare); Randomized controlled trial; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002838011,0.0006222252,0.001715389,0.0002277293,0.0002537627,0.0006486393,0.0004263178,0.0007592042,0.001894408],"category_scores_gemma":[0.001525296,0.0003045366,0.002006972,0.0002880635,0.0005714461,0.000458264,0.0003128314,0.001104932,0.0003099237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004126305,"about_ca_system_score_gemma":0.0008413711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000453835,"about_ca_topic_score_gemma":0.001560765,"domain_scores_codex":[0.9992738,0.0003997445,0.00007670002,0.00007323248,0.00008787044,0.00008860202],"domain_scores_gemma":[0.998727,0.0003666783,0.0003730633,0.0001290298,0.0001275502,0.0002767089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7844341,0.02503858,0.01958934,0.001976031,0.003953254,0.0001549871,0.0003651495,0.0007652012,0.02750284,0.0001438039,0.002242549,0.1338342],"study_design_scores_gemma":[0.3462899,0.5685015,0.07593156,0.0001356905,0.002505476,0.0002259407,0.00008270967,0.0005230439,0.002899075,0.0001035858,0.002755829,0.00004567418],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946573,0.003517168,0.0001813,0.0001994699,0.00005017569,0.0004348944,0.0003158739,0.00002753725,0.0006162194],"genre_scores_gemma":[0.995397,0.00181235,0.0006466786,0.000377314,0.0001384494,0.000399444,0.0006802215,0.000007964348,0.0005404596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002838011,"threshold_uncertainty_score":0.01500905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0085782671233336,"score_gpt":0.2559651077244041,"score_spread":0.2473868406010705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}