{"id":"W3210943555","doi":"10.3389/fgene.2021.784167","title":"Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability","year":2021,"lang":"en","type":"review","venue":"Frontiers in Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Government of Ontario","keywords":"Homologous recombination; Endonuclease; Nuclease; DNA; DNA repair; Helicase; Holliday junction; Biology; Genome; Genetics; Computational biology; Genome instability; Cell biology; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002666348,0.0003116138,0.0008180258,0.0001240268,0.00004420495,0.00002361996,0.0003319325,0.0002113242,0.00001051384],"category_scores_gemma":[0.00008989299,0.0002641741,0.0002156316,0.0002578584,0.0001805263,0.000002894783,0.0003735792,0.0002592303,3.924537e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005239865,"about_ca_system_score_gemma":0.0001698832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001420504,"about_ca_topic_score_gemma":0.0000458939,"domain_scores_codex":[0.9981489,0.0003364338,0.0005441015,0.0005436846,0.0001537285,0.0002732218],"domain_scores_gemma":[0.9989215,0.00002024266,0.0001686833,0.0007764523,0.00005016812,0.00006296612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004798871,0.0002370305,0.001548624,0.009680881,0.0007117559,0.00007620254,0.0004886267,0.0003191248,0.01477145,0.0001677463,0.000694418,0.9712561],"study_design_scores_gemma":[0.0004150904,0.0001824244,0.000726253,0.0009081154,0.0003823763,0.00005159914,0.0008227074,0.00004311702,0.005087283,0.0003309792,0.9903909,0.0006591644],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04389153,0.9535583,0.001324617,0.000005749953,0.0004895739,0.0005396295,0.0001472353,0.000005011117,0.00003838992],"genre_scores_gemma":[0.002987497,0.9894976,0.006999662,0.00001620296,0.00007329274,0.00009326579,0.000252545,0.00005256155,0.00002737822],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9896964,"threshold_uncertainty_score":0.999981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05878124303658952,"score_gpt":0.2726553898077212,"score_spread":0.2138741467711317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}