{"id":"W3210991186","doi":"10.1182/blood-2021-148949","title":"Glofitamab Step-up Dosing Induces High Response Rates in Patients (pts) with Relapsed or Refractory (R/R) Mantle Cell Lymphoma (MCL), Most of Whom Had Failed Prior Bruton's Tyrosine Kinase Inhibitor (BTKi) Therapy","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Obinutuzumab; Medicine; Mantle cell lymphoma; Tolerability; Internal medicine; Dosing; Gastroenterology; Cytokine release syndrome; Pharmacology; Rituximab; Lymphoma; Oncology; Adverse effect; Cancer; Immunotherapy; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004146057,0.0001537752,0.0004950287,0.0001597584,0.00009188955,0.0003616168,0.0001560646,0.0003300171,0.002457902],"category_scores_gemma":[0.001193737,0.0001121474,0.0003997137,0.0001625609,0.0001150439,0.0002350273,0.000176029,0.0008314854,0.0007714505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002386086,"about_ca_system_score_gemma":0.0001505608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002436321,"about_ca_topic_score_gemma":0.0004593572,"domain_scores_codex":[0.9997984,0.00005679308,0.00001581138,0.00004942643,0.0000449446,0.00003468548],"domain_scores_gemma":[0.9995764,0.0001295017,0.0001336543,0.0000478751,0.00002634667,0.00008615225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.07320988,0.006926335,0.1011983,0.0003828184,0.0005293785,0.0005385594,0.0003762215,0.00247391,0.1614469,0.0001659727,0.008158575,0.6445932],"study_design_scores_gemma":[0.01016672,0.1562203,0.7731612,0.00007811014,0.0006578384,0.004329383,0.0002471231,0.004864544,0.03464818,0.0003456595,0.01522729,0.00005373462],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996989,0.001155205,0.0002213535,0.0001335277,0.00001951971,0.00008431996,0.0002397212,0.00009574022,0.00106183],"genre_scores_gemma":[0.9985474,0.0002344449,0.0001925066,0.0002233571,0.00001310994,0.00003216227,0.0003061758,0.00001026585,0.0004407307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002457902,"threshold_uncertainty_score":0.008222461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01108137886392849,"score_gpt":0.2364690204649568,"score_spread":0.2253876416010283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}