{"id":"W3211004656","doi":"10.3390/cells10112966","title":"Positive Regulation of Estrogen Receptor Alpha in Breast Tumorigenesis","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Estrogen receptor alpha; Carcinogenesis; Estrogen receptor; Biology; Breast cancer; Cancer research; Estrogen; Regulation of gene expression; Gene expression; Chromatin; Transcription factor; Estrogen receptor beta; Cancer; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219041,0.0002731343,0.0007742536,0.00008718309,0.00002099513,0.000009468441,0.0001634779,0.0005581821,0.00004059314],"category_scores_gemma":[0.00001256115,0.0002433795,0.0004131427,0.0002317025,0.00005109451,0.000001912277,0.00009007372,0.0001613603,0.00003543522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003830928,"about_ca_system_score_gemma":0.0002606466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001268851,"about_ca_topic_score_gemma":6.058048e-7,"domain_scores_codex":[0.9986436,0.0002272715,0.0004113326,0.0004072251,0.0001066211,0.0002039183],"domain_scores_gemma":[0.9992422,0.00002697536,0.0002511668,0.0003440694,0.00006989035,0.00006571294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004412867,0.0002955222,0.00003386443,0.004768346,0.0006893097,0.00004264469,0.00003920607,0.00001825637,0.1955508,0.00009962969,0.004077741,0.7943406],"study_design_scores_gemma":[0.0003287748,0.0001660248,0.0000221624,0.006307423,0.0004657713,0.000141352,0.00001546412,0.000002513217,0.2136033,0.000004086633,0.7784243,0.0005188881],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002291481,0.9965298,0.00001039713,0.000005719055,0.00028318,0.0003697653,0.0001281337,0.000004797611,0.0003767723],"genre_scores_gemma":[0.0003025187,0.9969749,0.0001967486,0.000007255475,0.0002135449,0.00002725457,0.001623475,0.00004800561,0.0006062817],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7938217,"threshold_uncertainty_score":0.9924728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008150650287671136,"score_gpt":0.2621788668774913,"score_spread":0.2540282165898201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}