{"id":"W3211004656","doi":"10.3390/cells10112966","title":"Positive Regulation of Estrogen Receptor Alpha in Breast Tumorigenesis","year":2021,"lang":"en","type":"review","venue":"Cells","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Estrogen receptor alpha; Carcinogenesis; Estrogen receptor; Biology; Breast cancer; Cancer research; Estrogen; Regulation of gene expression; Gene expression; Chromatin; Transcription factor; Estrogen receptor beta; Cancer; Gene; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003714435,0.0005859165,0.0007488304,0.001484516,0.0001879198,0.0006125123,0.0005620946,0.0006542703,0.002742273],"category_scores_gemma":[0.0005177539,0.0001961119,0.0003030225,0.001467342,0.0002935337,0.0007726232,0.0005196944,0.001139238,0.001812737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004719394,"about_ca_system_score_gemma":0.0007655895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000662875,"about_ca_topic_score_gemma":0.001146406,"domain_scores_codex":[0.9998873,0.00001924966,0.00001712366,0.00002038124,0.00004453875,0.00001121536],"domain_scores_gemma":[0.9998407,0.00007249306,0.00002061533,0.000005126592,0.00004380499,0.00001708331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008062983,0.00004496941,0.0001594709,0.01682315,0.00007094782,0.0002494785,0.00006587087,0.0003679107,0.002726634,0.004197519,0.03648704,0.9387264],"study_design_scores_gemma":[0.00001277504,0.00007440457,0.0008184824,0.002719524,0.00007573522,0.001332453,0.0000349442,0.0000503171,0.0004974859,0.001538156,0.992834,0.00001185723],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001153784,0.9983022,0.0001001787,0.0002003418,0.000220306,0.000002626128,0.00001617772,0.000008080098,0.001034714],"genre_scores_gemma":[0.0005421528,0.9986265,0.00009235272,0.0001473167,0.0001139374,0.00000332698,0.0000234887,0.000001387052,0.0004495737],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002742273,"threshold_uncertainty_score":0.009173751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008150650287671136,"score_gpt":0.2621788668774913,"score_spread":0.2540282165898201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}