{"id":"W3211017459","doi":"10.1016/j.bpsc.2021.10.011","title":"Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes","year":2021,"lang":"en","type":"article","venue":"Biological Psychiatry Cognitive Neuroscience and Neuroimaging","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill Genome Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"H2020 European Research Council; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; National Institute on Aging; Horizon 2020; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; European Commission; Institute Pasteur De Lille; Sanofi; Fondation Claude Pompidou; Canadian Institutes of Health Research; Mutuelle Générale de l'Education Nationale; European Research Council; Université de Bordeaux; ZonMw; Institut National de la Santé et de la Recherche Médicale; HORIZON EUROPE Framework Programme; Agence Nationale de la Recherche; Fondation Leducq; Bundesministerium für Wissenschaft, Forschung und Wirtschaft; Fondation pour la Recherche Médicale; McGill University; Fondation de France; Bundesministerium für Bildung und Forschung; Boston University; Alzheimer's Association; Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease","keywords":"Neurodegeneration; Neuroscience; Pathological; Biology; Brain development; Psychology; Medicine; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000696448,0.0007033438,0.0004989433,0.002174569,0.0004657808,0.001033413,0.0005165388,0.0008161535,0.002944677],"category_scores_gemma":[0.002126126,0.0003230673,0.000434435,0.001289209,0.0006509418,0.0006879607,0.0005002114,0.0007756219,0.0003423976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004508832,"about_ca_system_score_gemma":0.0004129087,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007442312,"about_ca_topic_score_gemma":0.008844842,"domain_scores_codex":[0.999729,0.00003425048,0.0000129121,0.0001624016,0.00003331061,0.0000280815],"domain_scores_gemma":[0.998543,0.0004798491,0.0004322293,0.0001221132,0.0002985076,0.000124269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00104568,0.0002214531,0.6633871,0.00046716,0.001265691,0.002975571,0.002010855,0.001800952,0.1747675,0.009015937,0.002825251,0.1402168],"study_design_scores_gemma":[0.000007411596,0.0001447701,0.9872879,0.0000669759,0.0001175621,0.0007964004,0.0002688281,0.0002177447,0.004603451,0.004137104,0.002333796,0.00001806272],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9570468,0.01131129,0.0148725,0.001627919,0.0001178466,0.00003626043,0.006054033,0.0001975082,0.008735871],"genre_scores_gemma":[0.9826948,0.004454481,0.007196112,0.0004530096,0.0000922629,0.00004871097,0.001765189,0.0000703425,0.003225014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007442312,"threshold_uncertainty_score":0.01479799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07686199541153993,"score_gpt":0.3853017147655361,"score_spread":0.3084397193539962,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}