{"id":"W3211022792","doi":"10.1101/2021.10.28.465024","title":"Evolutionarily divergent mTOR remodels the translatome to drive rapid wound closure and regeneration","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Silk-based biomaterials and applications","field":"Materials Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Helen Hay Whitney Foundation; Canadian Institutes of Health Research; New York Stem Cell Foundation","keywords":"Axolotl; Biology; PI3K/AKT/mTOR pathway; Regeneration (biology); Cell biology; Translation (biology); mTORC1; Polysome; Signal transduction; Messenger RNA; Ribosome; Genetics; RNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000829111,0.0004755852,0.0004650635,0.0001198649,0.0005840682,0.0007683125,0.000586793,0.0004079515,0.000215416],"category_scores_gemma":[0.00008108137,0.0004013835,0.0001207749,0.0004102599,0.000178259,0.0001832266,0.0004533884,0.0002531707,0.0000794636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002004243,"about_ca_system_score_gemma":0.0005474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001031617,"about_ca_topic_score_gemma":0.00001226024,"domain_scores_codex":[0.9969869,0.0002534823,0.0005802637,0.001208959,0.0004996179,0.0004708217],"domain_scores_gemma":[0.9974943,0.00005829765,0.0002998017,0.00133643,0.000530981,0.000280189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002594363,0.00006192152,0.0003336864,0.00009717821,0.00003883716,0.000007251275,0.00007242039,0.0002589096,0.997566,0.001054666,0.0004805702,0.000002577882],"study_design_scores_gemma":[0.0002827533,0.00003908179,0.03532599,0.0001628111,0.0001227515,5.776975e-8,0.0000122494,0.0003405389,0.9596983,0.00001088954,0.003413144,0.0005914593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986954,0.00193317,0.005196325,0.002147009,0.001557406,0.001240946,0.000735888,0.0002321533,0.000003146559],"genre_scores_gemma":[0.9901029,0.0002376607,0.007764309,0.0004797944,0.0007422518,0.000593728,0.000002419042,0.0000704518,0.000006451738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03786777,"threshold_uncertainty_score":0.9998438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01707211220018836,"score_gpt":0.2243395296471195,"score_spread":0.2072674174469311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}