{"id":"W3211139087","doi":"10.1002/alz.12393","title":"The epidemiology is promising, but the trial evidence is weak. Why pharmacological dementia risk reduction trials haven't lived up to expectations, and where do we go from here?","year":2021,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Center for Diagnosis and Research on Alzheimer's Disease","funders":"National Health and Medical Research Council; National Institutes of Health; Dementia Centre for Research Collaboration; Dementias Platform UK; Medical Research Council; Alzheimer's Association; Eisai; National Institute for Health and Care Research; Alzheimer's Society; National Institute on Aging; Eli Lilly and Company","keywords":"Observational study; Dementia; Psychological intervention; Intervention (counseling); Clinical trial; Epidemiology; Randomized controlled trial; Medicine; Multidisciplinary approach; Psychology; Intensive care medicine; Psychiatry; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4093533,0.001989214,0.009115911,0.009105605,0.003096732,0.0196195,0.005563978,0.009097167,0.01683118],"category_scores_gemma":[0.6504431,0.00169625,0.008707684,0.01011018,0.01177062,0.03261049,0.005562701,0.01606884,0.005041909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01004643,"about_ca_system_score_gemma":0.03297011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008413701,"about_ca_topic_score_gemma":0.01623245,"domain_scores_codex":[0.7368546,0.1696085,0.05202305,0.0100515,0.02935728,0.002105028],"domain_scores_gemma":[0.1756212,0.7034624,0.04144884,0.02304779,0.05301806,0.00340172],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.003514244,0.0004140157,0.02162002,0.2476845,0.01757108,0.0004113354,0.002268327,0.001099104,0.0008665076,0.0774404,0.09247114,0.5346393],"study_design_scores_gemma":[0.002291779,0.001937,0.02662947,0.4852544,0.02358682,0.001193053,0.00504448,0.001537621,0.001482376,0.1844976,0.2659291,0.0006162818],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.001545697,0.5082483,0.01419897,0.4560695,0.01139295,0.000882308,0.0008394745,0.0001409511,0.006681825],"genre_scores_gemma":[0.07470993,0.5104399,0.0617385,0.3246076,0.02213941,0.002893037,0.001095297,0.000347972,0.002028464],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5906466,"threshold_uncertainty_score":0.7283725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1599110652959964,"score_gpt":0.4240140868889826,"score_spread":0.2641030215929863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}