{"id":"W3211156244","doi":"10.1007/s13555-021-00632-7","title":"A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis","year":2021,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Palmoplantar pustulosis; Medicine; Double blind; Placebo; Dermatology; Randomized controlled trial; Internal medicine; Psoriasis; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002333722,0.001429656,0.002907667,0.0005305308,0.0005801404,0.0007299105,0.0009279776,0.0017641,0.007413554],"category_scores_gemma":[0.001559999,0.0007696607,0.001164313,0.0003989622,0.0009663766,0.0008041901,0.0002905664,0.00200961,0.00125109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003827997,"about_ca_system_score_gemma":0.00133121,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004497961,"about_ca_topic_score_gemma":0.0009663504,"domain_scores_codex":[0.9992564,0.000390088,0.00005054392,0.0001342016,0.00007204494,0.00009665599],"domain_scores_gemma":[0.9989008,0.0002851939,0.0002630661,0.00009299738,0.0001193306,0.0003386806],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9388657,0.03050359,0.001042553,0.0008227825,0.0007962735,0.00009485646,0.00008650488,0.0001927263,0.01050555,0.0001068501,0.0009827049,0.01599997],"study_design_scores_gemma":[0.8535883,0.1431103,0.002039145,0.00001855288,0.0002031042,0.00004120705,0.00001442071,0.0001647085,0.0003440861,0.00004514536,0.0004227394,0.000008251894],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980229,0.003578585,0.001180232,0.0005500125,0.0004081009,0.01084066,0.00124402,0.0001932861,0.001776184],"genre_scores_gemma":[0.9732224,0.002689705,0.003369551,0.001702711,0.000582839,0.0138552,0.001409248,0.00002961408,0.003138754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007413554,"threshold_uncertainty_score":0.02480084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480674125765737,"score_gpt":0.2943839057382064,"score_spread":0.2695771644805491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}