{"id":"W3211156244","doi":"10.1007/s13555-021-00632-7","title":"A Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study to Evaluate the Efficacy and Safety of RIST4721 in Subjects with Palmoplantar Pustulosis","year":2021,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovaderm (Canada)","funders":"","keywords":"Palmoplantar pustulosis; Medicine; Double blind; Placebo; Dermatology; Randomized controlled trial; Internal medicine; Psoriasis; Alternative medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007441675,0.0002645837,0.001160019,0.0001378451,0.0002155965,0.00001448971,0.0001162654,0.0001523675,0.00008585246],"category_scores_gemma":[0.00004542795,0.0001482923,0.00008386746,0.0002168167,0.0002822367,0.00004257504,0.00004641802,0.0001709221,0.00001258513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008095731,"about_ca_system_score_gemma":0.00007340158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009951236,"about_ca_topic_score_gemma":0.0003490708,"domain_scores_codex":[0.9971567,0.001695435,0.0004406253,0.0003728095,0.00004729874,0.0002871552],"domain_scores_gemma":[0.9980323,0.001462432,0.0001136606,0.0002884672,0.00007056118,0.0000326316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9629876,0.001452097,0.02003481,0.00001095543,0.002532521,0.0001735043,0.005446983,0.000003954859,0.002130497,0.0002767669,0.00003201026,0.004918269],"study_design_scores_gemma":[0.9757308,0.0005096754,0.003501781,0.00002882021,0.0005214951,0.0008031586,0.001327702,0.000004677576,0.0169845,0.00007130093,0.0003377023,0.0001783655],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775658,0.01847811,0.00001977733,0.0007594359,0.0001476831,0.00277053,0.00001792883,0.00001745232,0.0002232471],"genre_scores_gemma":[0.9961294,0.003049631,0.00001769913,0.0002053093,0.00001054929,0.0004207717,0.00004276868,0.00001339091,0.0001104884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01856356,"threshold_uncertainty_score":0.6047185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02480674125765737,"score_gpt":0.2943839057382064,"score_spread":0.2695771644805491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}