{"id":"W3211208106","doi":"10.1038/s42003-021-02764-0","title":"A large Canadian cohort provides insights into the genetic architecture of human hair colour","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dairy Farmers of Ontario; General Electric (Canada); University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Consejo Nacional de Ciencia y Tecnología; Mitacs; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Government of Ontario; Compute Canada","keywords":"Genome-wide association study; Biology; Genetic architecture; Phenotype; Genetics; Expression quantitative trait loci; Evolutionary biology; Quantitative trait locus; Genetic association; Transcriptome; Single-nucleotide polymorphism; Gene; Genotype; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001179414,0.00007962329,0.0001038049,0.00004250373,0.0003153762,0.000009447086,0.0005512739,0.0001264786,0.00002765654],"category_scores_gemma":[0.00009280249,0.00006209525,0.00004825176,0.0001124176,0.0002266976,0.000001172812,0.0002487638,0.0001044023,0.000004926301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001879562,"about_ca_system_score_gemma":0.0002626552,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003691068,"about_ca_topic_score_gemma":0.241178,"domain_scores_codex":[0.9991273,0.0003459723,0.0001874225,0.0001654867,0.00003367446,0.0001401339],"domain_scores_gemma":[0.9984909,0.00003490495,0.00007191599,0.001214331,0.0001334244,0.00005457116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000008055044,0.0001031541,0.09398004,0.00001482825,0.0001424444,0.000001732482,0.001933972,0.00001318958,0.8842901,0.01574538,0.001617013,0.002150068],"study_design_scores_gemma":[0.0008451535,0.0004054297,0.135597,0.00002713147,0.00008574974,0.00004303512,0.001712026,0.0002151154,0.1775307,0.01043835,0.6727405,0.0003598449],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879185,0.005824565,0.0005851205,0.001721406,0.00006052524,0.0002343596,0.00001877236,0.000005927096,0.003630824],"genre_scores_gemma":[0.9956581,0.0007186566,0.001643343,0.0005718695,0.00003855636,0.00007242948,0.001012013,0.000008441481,0.0002765946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7067595,"threshold_uncertainty_score":0.7726685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377705625113309,"score_gpt":0.2894261132659748,"score_spread":0.2756490570148418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}