{"id":"W3211208106","doi":"10.1038/s42003-021-02764-0","title":"A large Canadian cohort provides insights into the genetic architecture of human hair colour","year":2021,"lang":"en","type":"article","venue":"Communications Biology","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dairy Farmers of Ontario; General Electric (Canada); University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services; Consejo Nacional de Ciencia y Tecnología; Mitacs; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Government of Ontario; Compute Canada","keywords":"Genome-wide association study; Biology; Genetic architecture; Phenotype; Genetics; Expression quantitative trait loci; Evolutionary biology; Quantitative trait locus; Genetic association; Transcriptome; Single-nucleotide polymorphism; Gene; Genotype; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007295322,0.0007189401,0.0005400615,0.001322699,0.002480735,0.0008939838,0.0005625903,0.0004149897,0.006559195],"category_scores_gemma":[0.001526349,0.0003060052,0.0007592569,0.002893752,0.0003807599,0.0002391947,0.00078653,0.0005943083,0.000606987],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004322892,"about_ca_system_score_gemma":0.005387814,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8876894,"about_ca_topic_score_gemma":0.949555,"domain_scores_codex":[0.9991449,0.00007191849,0.00002412839,0.0002580759,0.0003193889,0.0001814102],"domain_scores_gemma":[0.9992428,0.00006292127,0.00009009609,0.0001387971,0.0002859038,0.0001796208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006784452,0.0000821381,0.9334955,0.0002136574,0.0009435722,0.001134216,0.00118535,0.0004766643,0.01564721,0.001609534,0.01419573,0.03033801],"study_design_scores_gemma":[0.00003409323,0.00003578494,0.9900775,0.00003030216,0.0002033625,0.000407785,0.0002253168,0.0003029044,0.0004207792,0.0001936485,0.008046118,0.00002237981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9430072,0.003145087,0.006211302,0.001230105,0.000127981,0.0002250706,0.03090923,0.0001521082,0.01499203],"genre_scores_gemma":[0.9830381,0.001183062,0.003406684,0.0003218422,0.00003039379,0.00004973785,0.005878127,0.00007096855,0.006021128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1123106,"threshold_uncertainty_score":0.225944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377705625113309,"score_gpt":0.2894261132659748,"score_spread":0.2756490570148418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}