{"id":"W3211215366","doi":"10.1101/2021.10.26.465908","title":"HIV-1 envelope glycoproteins proteolytic cleavage protects infected cells from ADCC mediated by plasma from infected individuals","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Antibody-dependent cell-mediated cytotoxicity; Furin; Glycoprotein; Cleavage (geology); Epitope; Cell biology; Endoplasmic reticulum; Viral envelope; Chemistry; Endocytic cycle; Virology; Antibody; Biology; Molecular biology; Endocytosis; In vitro; Cell; Cytotoxicity; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001613225,0.0002203751,0.0002115055,0.0001077165,0.0001061131,0.0002252093,0.0002195588,0.0002829919,0.002411408],"category_scores_gemma":[0.000181113,0.0001021006,0.0001411356,0.00006852153,0.0001437055,0.0001042183,0.0001597449,0.0004610792,0.0005247636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001375249,"about_ca_system_score_gemma":0.0001107471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003586691,"about_ca_topic_score_gemma":0.0002696691,"domain_scores_codex":[0.9998846,0.00002860993,0.000007305066,0.00001378129,0.00003271104,0.00003308734],"domain_scores_gemma":[0.9999055,0.00003044117,0.00001244288,0.00001941787,0.00001636787,0.00001589746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003005723,0.00004619614,0.0003226052,0.00002619748,0.000007515351,0.0000594602,0.00001757162,0.00007714362,0.9967117,0.00007704282,0.00009903018,0.002254931],"study_design_scores_gemma":[0.00004665415,0.0005332135,0.005898582,0.000007693476,0.00001072357,0.0003625604,0.00001444782,0.0007015279,0.9909102,0.00008178841,0.001429365,0.000003239582],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953979,0.001104313,0.001422805,0.00008965685,0.00002493328,0.00002726622,0.0002578715,0.00004923076,0.001626023],"genre_scores_gemma":[0.9967796,0.0001770061,0.0006816186,0.00005361184,0.000008281219,0.00001288782,0.0003156035,0.00000975287,0.001961715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002411408,"threshold_uncertainty_score":0.008066893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00982150497704819,"score_gpt":0.2058857506681876,"score_spread":0.1960642456911394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}