{"id":"W3211235931","doi":"10.1038/s41467-021-26489-0","title":"Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Princess Margaret Cancer Centre; St. Michael's Hospital; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; National Cancer Institute; University of Toronto; Prostate Cancer Canada; Government of Ontario; Canadian Cancer Society Research Institute; National Institutes of Health; Ontario Genomics; Genome Canada; Cancer Research UK; Government of Canada; Ontario Institute for Cancer Research; Ontario Genomics Institute; Movember Foundation","keywords":"Prostate cancer; Biology; Somatic cell; Genome instability; Cancer research; Metastasis; Disease; Oncology; Cancer; Gene; Medicine; Genetics; Internal medicine; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501186,0.0001013815,0.0002097762,0.0008621509,0.0001572507,0.0001975883,0.0001633905,0.000141937,0.001543297],"category_scores_gemma":[0.000361638,0.0001023818,0.0001879466,0.0005343762,0.0001609614,0.0000847952,0.0001857312,0.0001374959,0.0001702793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688937,"about_ca_system_score_gemma":0.0001263054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002415489,"about_ca_topic_score_gemma":0.005480829,"domain_scores_codex":[0.9998821,0.00001426133,0.00001008497,0.00003316409,0.00003642384,0.00002384205],"domain_scores_gemma":[0.9997618,0.00005132622,0.0001027697,0.00002160145,0.00001891681,0.00004363214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002135262,0.00001996295,0.9826316,0.00001314683,0.00005183588,0.0001472838,0.00003815779,0.0001043586,0.01175964,0.0000220805,0.00009856714,0.004899894],"study_design_scores_gemma":[0.000004176078,0.00006422687,0.997355,0.000001303256,0.00002266616,0.0008413111,0.00003389913,0.0002351608,0.001253537,0.00001856913,0.0001680569,0.000002042569],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995148,0.000084509,0.00006966493,0.000005217664,5.630898e-7,0.000002323713,0.0002202659,0.000006968569,0.00009571176],"genre_scores_gemma":[0.9993393,0.00003404681,0.00009399612,0.000003410509,0.000001451338,0.000002352714,0.0003934471,0.000001991097,0.0001299818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002415489,"threshold_uncertainty_score":0.005162776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02616332556755274,"score_gpt":0.3624327021093147,"score_spread":0.336269376541762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}