{"id":"W3211246527","doi":"10.14309/01.ajg.0000778040.44734.f8","title":"S1127 Safety and Efficacy of Switching to Tenofovir Alafenamide (TAF) in Virally Suppressed Chronic Hepatitis B (CHB) Patients With Renal Impairment: Week 48 Results From a Phase 2 Open-Label Study","year":2021,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre; University of Calgary; University Health Network","funders":"","keywords":"Medicine; Tenofovir alafenamide; Internal medicine; Gastroenterology; Dialysis; Creatinine; Renal function; Urology; HBeAg; HBsAg; Hepatitis B; Kidney disease; Tenofovir; Nephropathy; Hepatitis B virus; Viral load; Endocrinology; Immunology; Virus; Diabetes mellitus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00122196,0.0007079064,0.001720733,0.0002322732,0.0003308614,0.000743598,0.0003879904,0.001129564,0.003204967],"category_scores_gemma":[0.001008929,0.0003583838,0.001264181,0.0002845085,0.0004673345,0.0005664644,0.0002110848,0.001621851,0.0007417801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003641338,"about_ca_system_score_gemma":0.0006020307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000345324,"about_ca_topic_score_gemma":0.0005927323,"domain_scores_codex":[0.9995053,0.0002283432,0.00005000956,0.00007817251,0.00006938069,0.00006881884],"domain_scores_gemma":[0.9992175,0.0001769542,0.000241677,0.00006764576,0.00007315785,0.0002230199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8096265,0.03365118,0.01978137,0.0007247794,0.001650652,0.0002232676,0.0002248175,0.0009027771,0.03451671,0.00006980007,0.001551371,0.09707669],"study_design_scores_gemma":[0.4026259,0.5373433,0.05081413,0.00007487663,0.0007996553,0.0003943985,0.00006120654,0.001278647,0.00458448,0.0001051974,0.001867872,0.00005029976],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980428,0.0007262968,0.0001194626,0.000074993,0.00002773479,0.0003062524,0.0002690617,0.00002248321,0.0004108362],"genre_scores_gemma":[0.9969262,0.0004916844,0.0003582076,0.0002460871,0.00007673196,0.0005106254,0.0007193417,0.000007579018,0.0006635556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003204967,"threshold_uncertainty_score":0.01072168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01433691612290779,"score_gpt":0.2919217638252026,"score_spread":0.2775848477022948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}