{"id":"W3211352653","doi":"10.1182/blood-2021-145854","title":"Transcriptomic Features of Immune Exhaustion and Senescence Predict Outcomes and Define Checkpoint Blockade-Unresponsive Microenvironments in Acute Myeloid Leukemia","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Immune checkpoint; Myeloid leukemia; Medicine; Oncology; Internal medicine; Immunology; Immune system; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001667141,0.0001248807,0.0001991734,0.0004338258,0.0001469722,0.0003369972,0.0001115714,0.0001660092,0.0009017096],"category_scores_gemma":[0.0002726275,0.00008923736,0.0001425539,0.0004226741,0.0001416758,0.0001190831,0.0002436202,0.0001926763,0.0001875539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001277233,"about_ca_system_score_gemma":0.0001024667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005170556,"about_ca_topic_score_gemma":0.0009455384,"domain_scores_codex":[0.9998991,0.00001616104,0.00001114755,0.00003037387,0.00001663495,0.00002637541],"domain_scores_gemma":[0.9998561,0.00002321795,0.00006863461,0.00001322329,0.00001953198,0.00001925591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00123525,0.0001009831,0.7790852,0.0000837809,0.000109976,0.0002557876,0.0002178905,0.0004002005,0.20506,0.00008333434,0.0003520551,0.01301559],"study_design_scores_gemma":[0.00001316483,0.0001457636,0.991397,0.000006798611,0.00004117944,0.0003502166,0.0001831967,0.0007798527,0.006092928,0.00007216397,0.0009135145,0.000004059783],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985778,0.0004011552,0.0002209243,0.00001843375,0.000002671753,0.000006403448,0.000629844,0.000005142348,0.0001375951],"genre_scores_gemma":[0.998432,0.0001351119,0.0002292928,0.00002747453,0.000007110305,0.00001507851,0.0009192495,0.00000211396,0.0002325558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009017096,"threshold_uncertainty_score":0.003016472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00876558264766543,"score_gpt":0.2490463395564558,"score_spread":0.2402807569087904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}