{"id":"W3211353650","doi":"10.3389/fcvm.2021.767488","title":"Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger","year":2021,"lang":"en","type":"review","venue":"Frontiers in Cardiovascular Medicine","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cumming School of Medicine, University of Calgary","keywords":"Microvesicles; Medicine; Disease; Paracrine signalling; Exosome; Progenitor cell; Extracellular vesicles; Microvesicle; Bioinformatics; microRNA; Neuroscience; Stem cell; Biology; Cell biology; Pathology; Gene; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000492466,0.0007351012,0.001008981,0.001593606,0.0003226865,0.001173247,0.0005903966,0.001382333,0.002603782],"category_scores_gemma":[0.0005931273,0.0001911553,0.0004804708,0.001045805,0.0006328102,0.001552936,0.001017607,0.001856245,0.001412109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005141743,"about_ca_system_score_gemma":0.0008507055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000366182,"about_ca_topic_score_gemma":0.0005613749,"domain_scores_codex":[0.9998222,0.00004308822,0.00002321274,0.00002804748,0.00006518536,0.00001827158],"domain_scores_gemma":[0.9997547,0.0001394627,0.00002313797,0.00001004584,0.00005009819,0.00002253576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007749534,0.0000608565,0.0002614128,0.01358027,0.00008399574,0.000423206,0.0001337229,0.0004030905,0.005849792,0.01545853,0.03224752,0.9314202],"study_design_scores_gemma":[0.000009728148,0.00007588196,0.0006680925,0.002400624,0.00005448066,0.001890541,0.00006570343,0.000113661,0.00137435,0.005226722,0.9881012,0.00001890412],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001108839,0.998225,0.0002046118,0.0003189008,0.0002941549,0.000003013532,0.00001107026,0.000006637417,0.0008256373],"genre_scores_gemma":[0.001173623,0.9973786,0.0002127688,0.0002096562,0.0002997969,0.000007256203,0.00002177855,0.000001791672,0.0006948704],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002603782,"threshold_uncertainty_score":0.008710504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01289045231886349,"score_gpt":0.2649111624265517,"score_spread":0.2520207101076882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}