{"id":"W3211360047","doi":"10.1182/blood-2021-153166","title":"Preliminary Safety and Efficacy of PBCAR0191, an Allogeneic 'Off-the-Shelf' CD19-Directed CAR-T for Patients with Relapsed/Refractory (R/R) CD19+ B-ALL","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Fludarabine; Population; Internal medicine; Cyclophosphamide; Refractory (planetary science); CAR T-cell therapy; Immunology; Gastroenterology; T cell; Chemotherapy; Chimeric antigen receptor; Biology; Immune system","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007524259,0.0004047382,0.0004329023,0.0001326422,0.0002532522,0.000339057,0.0001768458,0.0003657879,0.00150802],"category_scores_gemma":[0.0006841022,0.0001411189,0.000333186,0.00008720761,0.0003473099,0.0002545706,0.0001304054,0.0008933417,0.0004554487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002339959,"about_ca_system_score_gemma":0.0002824907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003303583,"about_ca_topic_score_gemma":0.0004809998,"domain_scores_codex":[0.9998093,0.0001024631,0.00001695417,0.00002004112,0.00002025436,0.00003100961],"domain_scores_gemma":[0.9995146,0.0002162922,0.00007788971,0.0000537813,0.00003178279,0.0001056016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2507837,0.03157227,0.07723471,0.0007301344,0.0005079509,0.002647137,0.000989662,0.002607467,0.3706892,0.0002557228,0.004697171,0.2572849],"study_design_scores_gemma":[0.02809115,0.7258185,0.1440341,0.00007476217,0.0007434972,0.004055162,0.0001648668,0.001935834,0.08532757,0.0001694747,0.00954977,0.0000352613],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973226,0.0006204516,0.0003407576,0.0001008073,0.00001826089,0.0001182925,0.000199829,0.00003974705,0.001239144],"genre_scores_gemma":[0.9986295,0.0002094214,0.0001777219,0.00008789496,0.00003397393,0.00006294799,0.0003720099,0.000005767848,0.0004207956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00150802,"threshold_uncertainty_score":0.005044878,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0173930089100476,"score_gpt":0.2749539471231319,"score_spread":0.2575609382130843,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}