{"id":"W3211365173","doi":"10.3390/cells10113063","title":"RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Courtois Foundation; Compute Canada; Université du Québec à Montréal","keywords":"Endosome; Biology; Cell biology; Immunoprecipitation; Colocalization; Gene knockdown; Protein subunit; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252394,0.000461283,0.0002088984,0.0001572811,0.0001849645,0.0001973009,0.0002586352,0.000320476,0.0009189218],"category_scores_gemma":[0.0001384615,0.0001025237,0.0002023742,0.0001389931,0.0002272764,0.0001068803,0.0001881448,0.0003014946,0.0004207515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000442536,"about_ca_system_score_gemma":0.0002012525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009482919,"about_ca_topic_score_gemma":0.001567684,"domain_scores_codex":[0.9998363,0.00003956192,0.00002173001,0.00002843677,0.00004594233,0.00002802825],"domain_scores_gemma":[0.9998945,0.00002241918,0.00003775795,0.00001376669,0.000008942149,0.00002255478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006211708,0.00001649094,0.0001214859,0.00001005568,0.000004322006,0.0001071102,0.000005107792,0.00005349375,0.9989635,0.00005442853,0.00002375549,0.0005780869],"study_design_scores_gemma":[0.00001073513,0.00007702933,0.002392577,0.000002532807,0.000006788346,0.0004444681,0.00001175332,0.0008033682,0.9950272,0.00002978836,0.001190244,0.000003461657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952568,0.0004352877,0.002916268,0.00007219361,0.0000183546,0.0000237247,0.0003244986,0.00007992583,0.0008728812],"genre_scores_gemma":[0.9955755,0.0002794467,0.001926814,0.00003758625,0.00000366724,0.0000277025,0.0004446003,0.00003558524,0.001669065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009482919,"threshold_uncertainty_score":0.003210843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006550434617991654,"score_gpt":0.1906116250486446,"score_spread":0.1840611904306529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}