{"id":"W3211365173","doi":"10.3390/cells10113063","title":"RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association","year":2021,"lang":"en","type":"article","venue":"Cells","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Courtois Foundation; Compute Canada; Université du Québec à Montréal","keywords":"Endosome; Biology; Cell biology; Immunoprecipitation; Colocalization; Gene knockdown; Protein subunit; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006429522,0.00009423523,0.0001031336,0.0000151343,0.00005423319,0.00003195852,0.00002833918,0.0001039256,0.00006144334],"category_scores_gemma":[0.00001141379,0.00008835276,0.0000187484,0.00004943434,0.00002699006,0.000004937247,0.00002662803,0.00004728605,0.000002484944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001138598,"about_ca_system_score_gemma":0.00002328693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001234229,"about_ca_topic_score_gemma":0.00008432652,"domain_scores_codex":[0.9994219,0.00003244814,0.0001079755,0.0002399375,0.00008016171,0.0001175748],"domain_scores_gemma":[0.9996992,0.000007220401,0.00005144193,0.0001109434,0.00007839813,0.00005277589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004615906,0.0000322739,0.02903542,0.00003599692,0.00003976241,0.00001151369,0.00009340588,0.00003410699,0.9697905,0.00003887249,0.0001255742,0.0007164056],"study_design_scores_gemma":[0.002178624,0.0003590042,0.1070809,0.00005692389,0.0001146453,0.00004729886,0.0001933397,0.002856649,0.8516761,0.00007157621,0.03501146,0.000353506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9441142,0.0005192446,0.05409758,0.0001176404,0.00007383712,0.00009266703,0.00002145313,0.000009270429,0.0009540723],"genre_scores_gemma":[0.9960756,0.0003906344,0.000283034,0.0001340102,0.0000847414,0.000002668032,0.002147177,0.00001274577,0.0008694043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1181144,"threshold_uncertainty_score":0.3602921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006550434617991654,"score_gpt":0.1906116250486446,"score_spread":0.1840611904306529,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}