{"id":"W3211377756","doi":"10.1182/blood-2021-152662","title":"DREAMM-5 Study: Investigating the Synergetic Effects of Belantamab Mafodotin Plus Inducible T-Cell Co-Stimulator Agonist (aICOS) Combination Therapy in Patients with Relapsed/Refractory Multiple Myeloma","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Vancouver General Hospital","funders":"","keywords":"Tolerability; Medicine; Multiple myeloma; Oncology; Refractory (planetary science); Interim analysis; Lenalidomide; Phases of clinical research; Internal medicine; Pharmacology; Clinical trial; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002268452,0.0009690062,0.001829686,0.0002923133,0.0002941391,0.0009730476,0.0008994298,0.0007489064,0.00321023],"category_scores_gemma":[0.0007337334,0.0004555334,0.001520197,0.0003370633,0.0004182647,0.0006799016,0.0004431756,0.002156449,0.000648542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00130356,"about_ca_system_score_gemma":0.001482637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009728247,"about_ca_topic_score_gemma":0.002917662,"domain_scores_codex":[0.9993294,0.0003345714,0.00004938685,0.0001233677,0.0000825188,0.00008061479],"domain_scores_gemma":[0.9995442,0.0000728081,0.0001048819,0.00004483776,0.00003434288,0.000198998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.745868,0.033708,0.01524214,0.002162942,0.004995181,0.0002629059,0.0004129692,0.00291897,0.04307166,0.0005854222,0.004425648,0.1463461],"study_design_scores_gemma":[0.4171228,0.5380914,0.02715041,0.00008254356,0.001927328,0.0004198858,0.0001068387,0.00157464,0.00522795,0.000233624,0.00801764,0.00004489113],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873806,0.005702497,0.0005224957,0.0004458527,0.0001186019,0.001788934,0.001280237,0.00009134546,0.002669264],"genre_scores_gemma":[0.9916984,0.001466212,0.001472805,0.0005543812,0.0001504349,0.001210663,0.001558825,0.00001584644,0.00187234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00321023,"threshold_uncertainty_score":0.01199687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01478820906808422,"score_gpt":0.2600192719463961,"score_spread":0.2452310628783119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}