{"id":"W3211389104","doi":"10.1016/s1474-4422(21)00364-1","title":"Safety and efficacy of teriflunomide in paediatric multiple sclerosis (TERIKIDS): a multicentre, double-blind, phase 3, randomised, placebo-controlled trial","year":2021,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; NeuroRx Research (Canada); McGill University","funders":"Sanofi","keywords":"Teriflunomide; Medicine; Placebo; Multiple sclerosis; Double blind; Phase (matter); Physical therapy; Pediatrics; Internal medicine; Alternative medicine; Psychiatry; Pathology; Fingolimod; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002205768,0.001664213,0.00404155,0.0003989082,0.0004630196,0.0009391467,0.0009108359,0.002578701,0.003831369],"category_scores_gemma":[0.002512821,0.0006695961,0.002498027,0.0004346013,0.001226007,0.001099538,0.0003842046,0.003071034,0.0006651109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007407954,"about_ca_system_score_gemma":0.001059578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007590182,"about_ca_topic_score_gemma":0.001259603,"domain_scores_codex":[0.9992025,0.0004032135,0.00007913898,0.0001407637,0.00008017645,0.00009417949],"domain_scores_gemma":[0.9987944,0.0003693184,0.0004138571,0.00008315304,0.00007018528,0.0002690749],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9746836,0.002598471,0.0007780005,0.001605812,0.001380419,0.00008851307,0.00007862769,0.0001916276,0.003212553,0.000116221,0.0006441665,0.01462183],"study_design_scores_gemma":[0.9600964,0.03629573,0.001973456,0.00007656752,0.000529873,0.00006585436,0.0000189956,0.0001177952,0.0003040409,0.00007285625,0.0004359259,0.00001252908],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733396,0.01943847,0.000695175,0.0008770587,0.0005829886,0.002685378,0.0009778617,0.0001018299,0.001301762],"genre_scores_gemma":[0.9770249,0.009989936,0.002465814,0.001462653,0.0006653786,0.005268153,0.001058797,0.00003393028,0.002030379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00404155,"threshold_uncertainty_score":0.01281714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08451433072359477,"score_gpt":0.3371328027371808,"score_spread":0.252618472013586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}