{"id":"W3211411127","doi":"10.25251/skin.5.supp.39","title":"Deucravacitinib, an Oral, Selective Tyrosine Kinase 2 (TYK2) Inhibitor, Versus Placebo and Apremilast in Moderate to Severe Plaque Psoriasis: Onset of Action in the Phase 3 POETYK PSO-1 and POETYK PSO-2 Trials","year":2021,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Bristol-Myers Squibb","keywords":"Apremilast; Medicine; Placebo; Psoriasis; Plaque psoriasis; Pharmacology; Internal medicine; Dermatology; Pathology; Psoriatic arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001108083,0.0005765026,0.001772583,0.0002202237,0.0002653796,0.0008087815,0.0003850741,0.0007332842,0.006108955],"category_scores_gemma":[0.0008843767,0.0002570613,0.001182524,0.0002086771,0.000379763,0.0007891132,0.0001738297,0.001715361,0.0006532783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005492446,"about_ca_system_score_gemma":0.0005904816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007436334,"about_ca_topic_score_gemma":0.002637198,"domain_scores_codex":[0.9996525,0.0001637277,0.00002544679,0.00005109733,0.00003742752,0.00006969493],"domain_scores_gemma":[0.9995725,0.0001299865,0.00008498491,0.00001929332,0.00002462477,0.0001686818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8534293,0.003056906,0.0007214236,0.001191432,0.001084078,0.00006732572,0.00005317539,0.0006320055,0.01113604,0.0002597774,0.004641251,0.1237274],"study_design_scores_gemma":[0.7726902,0.1975551,0.01445281,0.0002098247,0.001423854,0.0003493743,0.00008535592,0.001434145,0.003777519,0.0005721715,0.007396142,0.00005349808],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9520652,0.03286281,0.0007731768,0.001448687,0.0007143556,0.0009147536,0.001644874,0.0002874151,0.009288905],"genre_scores_gemma":[0.9849642,0.007589847,0.000588107,0.0007271031,0.0002710549,0.0004152053,0.0009551571,0.0000240917,0.004465351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006108955,"threshold_uncertainty_score":0.02043653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0500499621949942,"score_gpt":0.3309860334903083,"score_spread":0.2809360712953141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}