{"id":"W3211412243","doi":"10.25251/skin.5.supp.34","title":"Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Efficacy by Baseline Disease Characteristics and Demographics in Two Pivotal Phase 3 Trials","year":2021,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Phytochemistry Medicinal Plant Applications","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Allergan; Genentech; Astellas Pharma; Glenmark Pharmaceuticals; Pfizer; Biogen; Incyte; Sun Pharma; Dermira; Coherus Biosciences; Valeant Pharmaceuticals International; Ablynx; Celgene; Novartis; GlaxoSmithKline; Astellas Pharma US; Amgen; Galderma; LEO Pharma; Ortho Dermatologics; Eli Lilly and Company; Bristol-Myers Squibb; Bausch Health; Bayer HealthCare; Sanofi; Regeneron Pharmaceuticals; Abbott Laboratories","keywords":"Demographics; Plaque psoriasis; Medicine; Baseline (sea); Psoriasis; Disease; Internal medicine; Clinical trial; Dermatology; Demography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002145589,0.0001690086,0.0005774659,0.00001828756,0.0001327744,0.00001771616,0.000263475,0.00004985522,0.00008684712],"category_scores_gemma":[0.004769281,0.00005973144,0.00009704235,0.0003108451,0.0001869403,0.00004700881,0.00002985374,0.0002927758,5.456654e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000237352,"about_ca_system_score_gemma":0.0000551469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000149712,"about_ca_topic_score_gemma":0.00004419344,"domain_scores_codex":[0.998085,0.0002976839,0.0008735863,0.0001712584,0.0003527152,0.0002197756],"domain_scores_gemma":[0.993176,0.005593452,0.0006226788,0.00008916405,0.0002379472,0.0002807557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004425922,0.001207088,0.0008608411,0.0000608345,0.0001085897,0.0005397449,0.0002678793,0.00001294302,0.8980996,0.00005668444,0.0229983,0.07136158],"study_design_scores_gemma":[0.08080178,0.02126415,0.0299926,0.01129017,0.009134811,0.05864074,0.01540827,0.00807957,0.1121302,0.0162442,0.6334092,0.003604274],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9768268,0.00374273,0.0002448654,0.01819071,0.0001705653,0.0003419281,0.0004435469,0.000008699329,0.00003011367],"genre_scores_gemma":[0.9942127,0.00318053,0.00008583318,0.0005650179,0.001606347,0.00001001178,0.0002507657,0.000002299032,0.00008653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7859694,"threshold_uncertainty_score":0.570962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03108208345977064,"score_gpt":0.3264702968169979,"score_spread":0.2953882133572272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}