{"id":"W3211412243","doi":"10.25251/skin.5.supp.34","title":"Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Efficacy by Baseline Disease Characteristics and Demographics in Two Pivotal Phase 3 Trials","year":2021,"lang":"en","type":"article","venue":"SKIN The Journal of Cutaneous Medicine","topic":"Phytochemistry Medicinal Plant Applications","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Allergan; Genentech; Astellas Pharma; Glenmark Pharmaceuticals; Pfizer; Biogen; Incyte; Sun Pharma; Dermira; Coherus Biosciences; Valeant Pharmaceuticals International; Ablynx; Celgene; Novartis; GlaxoSmithKline; Astellas Pharma US; Amgen; Galderma; LEO Pharma; Ortho Dermatologics; Eli Lilly and Company; Bristol-Myers Squibb; Bausch Health; Bayer HealthCare; Sanofi; Regeneron Pharmaceuticals; Abbott Laboratories","keywords":"Demographics; Plaque psoriasis; Medicine; Baseline (sea); Psoriasis; Disease; Internal medicine; Clinical trial; Dermatology; Demography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002200161,0.001467768,0.002649596,0.0005007791,0.0004674314,0.001072277,0.0008712113,0.001286193,0.007812676],"category_scores_gemma":[0.001262531,0.0006728708,0.002349961,0.0005255811,0.0007561794,0.0009747628,0.0003172846,0.002815013,0.001122022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006382552,"about_ca_system_score_gemma":0.0009236936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022306,"about_ca_topic_score_gemma":0.00337924,"domain_scores_codex":[0.9993834,0.0002615989,0.00003967118,0.0001026697,0.00008303735,0.0001295625],"domain_scores_gemma":[0.9993652,0.0001852018,0.0001480154,0.00005342332,0.00005183381,0.0001964192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8562308,0.01610705,0.001973043,0.001748003,0.002182311,0.00009404733,0.000135016,0.0007414268,0.01623086,0.000234137,0.004224813,0.1000985],"study_design_scores_gemma":[0.8525223,0.1321579,0.009926877,0.0001203759,0.001250415,0.0001050721,0.00004125226,0.0004205856,0.0009126297,0.0002279947,0.002280147,0.00003449537],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623444,0.02049222,0.001498746,0.001480279,0.0004826846,0.004432742,0.003209158,0.0002959698,0.005763901],"genre_scores_gemma":[0.9741344,0.01176426,0.001983576,0.001843005,0.0004113554,0.003402328,0.002423605,0.00006082892,0.003976593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007812676,"threshold_uncertainty_score":0.02613604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03108208345977064,"score_gpt":0.3264702968169979,"score_spread":0.2953882133572272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}