{"id":"W3211442768","doi":"10.1182/blood-2021-147593","title":"Outcomes for Patients with Late-Stage Mutant-<i>IDH2</i> (m <i>IDH2</i>) Relapsed/Refractory Acute Myeloid Leukemia (R/R AML) Treated with Enasidenib Vs Other Lower-Intensity Therapies in the Randomized, Phase 3 IDHentify Trial","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"IDH2; Myeloid leukemia; Refractory (planetary science); Medicine; Stage (stratigraphy); Internal medicine; Oncology; Leukemia; Mutant; Cancer research; IDH1; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004039267,0.0003732022,0.0006172715,0.00005998341,0.0001467906,0.00009230946,0.0002537567,0.0002148011,0.00003538997],"category_scores_gemma":[0.0001950549,0.0002146916,0.0002692419,0.0001807417,0.0001934825,0.00002372127,0.00005123054,0.0002079921,0.000004507431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002851143,"about_ca_system_score_gemma":0.0002045618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006145034,"about_ca_topic_score_gemma":0.0001735042,"domain_scores_codex":[0.9980046,0.0002990015,0.0004512667,0.0005645296,0.0003158258,0.0003647495],"domain_scores_gemma":[0.9986367,0.0001169597,0.0002762867,0.0006200536,0.0002735215,0.0000765013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8537127,0.005367518,0.01626618,0.00005077543,0.002593019,0.0001509539,0.0006091238,0.00001394801,0.119457,0.00007489511,0.000998071,0.0007058367],"study_design_scores_gemma":[0.6860061,0.002261542,0.0005637046,0.00004307604,0.0003956436,0.000008061128,0.0001359732,0.000009622141,0.2988117,0.00002138164,0.01133902,0.0004041634],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964069,0.0002407279,0.0002986384,0.000244663,0.0001854054,0.00212674,0.0002196269,0.00003150882,0.0002457559],"genre_scores_gemma":[0.9952441,0.0001317282,0.0003944784,0.001398745,0.0001493549,0.0003706517,0.0005793416,0.00006162927,0.001670001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1793547,"threshold_uncertainty_score":0.8754868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00856959204541249,"score_gpt":0.2400686302749679,"score_spread":0.2314990382295554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}