{"id":"W3211442768","doi":"10.1182/blood-2021-147593","title":"Outcomes for Patients with Late-Stage Mutant-<i>IDH2</i> (m <i>IDH2</i>) Relapsed/Refractory Acute Myeloid Leukemia (R/R AML) Treated with Enasidenib Vs Other Lower-Intensity Therapies in the Randomized, Phase 3 IDHentify Trial","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"IDH2; Myeloid leukemia; Refractory (planetary science); Medicine; Stage (stratigraphy); Internal medicine; Oncology; Leukemia; Mutant; Cancer research; IDH1; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001327345,0.0007747171,0.001272586,0.0001616654,0.0003197613,0.0008863794,0.0004370839,0.0007903463,0.002688283],"category_scores_gemma":[0.0008455161,0.0002145407,0.001660816,0.0002096579,0.0004925632,0.0005973513,0.000436445,0.002328385,0.000348579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006452998,"about_ca_system_score_gemma":0.0008417552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004972673,"about_ca_topic_score_gemma":0.00115725,"domain_scores_codex":[0.9996897,0.0001368927,0.00002371135,0.0000681638,0.00002373307,0.0000578779],"domain_scores_gemma":[0.9993617,0.000116885,0.0001740418,0.00005291749,0.00004438998,0.000250081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9469606,0.009655782,0.01322348,0.0004308575,0.001560928,0.00007731859,0.0000788374,0.001355528,0.004955672,0.0002592766,0.002758995,0.01868275],"study_design_scores_gemma":[0.7164285,0.2366592,0.03579916,0.0001113114,0.002731972,0.0002754645,0.0001046244,0.001945502,0.002425032,0.0007271877,0.002746529,0.00004544178],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950646,0.001286237,0.0001966987,0.0002607383,0.0001293327,0.0005633723,0.001113076,0.00002325139,0.00136269],"genre_scores_gemma":[0.9941124,0.0006177044,0.0003443372,0.000604996,0.0001546283,0.0008783449,0.002307832,0.000008242183,0.000971426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002688283,"threshold_uncertainty_score":0.008993208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00856959204541249,"score_gpt":0.2400686302749679,"score_spread":0.2314990382295554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}